Document Detail

Therapeutic effects of resveratrol during acute periods following experimental ischemic stroke.
MedLine Citation:
PMID:  20655115     Owner:  NLM     Status:  MEDLINE    
We defined whether resveratrol administration during the acute phase of ischemic stroke reduces brain injury in mice. Infarct volumes were decreased significantly in both sexes with different doses of resveratrol (5mg/kg for males and 1mg/kg for females) administered 3h after ischemic stroke. Administration of resveratrol 6h after insult was also effective to decrease infarct volumes. Resveratrol suppressed expressions of IL-1β and TNF-α, microglial activation, and ROS production in the ischemic cortex. The findings suggest that the suppression of inflammation is partly associated with the neuroprotective effects of resveratrol, and resveratrol can be developed as a therapeutic drug for acute ischemic stroke.
Jin A Shin; Hyunah Lee; Yoo-Kyoung Lim; Yaekyu Koh; Ji Ha Choi; Eun-Mi Park
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-07-23
Journal Detail:
Title:  Journal of neuroimmunology     Volume:  227     ISSN:  1872-8421     ISO Abbreviation:  J. Neuroimmunol.     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2010-10-19     Revised Date:  2013-06-03    
Medline Journal Info:
Nlm Unique ID:  8109498     Medline TA:  J Neuroimmunol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  93-100     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier B.V. All rights reserved.
Department of Pharmacology, Ewha Medical Research Institute, School of Medicine, Ewha Womans University, Seoul, Republic of Korea.
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MeSH Terms
Acute Disease
Brain Infarction / drug therapy,  immunology,  metabolism
Brain Ischemia / drug therapy*,  immunology,  metabolism
Disease Models, Animal
Dose-Response Relationship, Immunologic
Inflammation Mediators / antagonists & inhibitors,  therapeutic use*
Mice, Inbred C57BL
Neuroprotective Agents / therapeutic use*
Reactive Oxygen Species / metabolism
Stilbenes / therapeutic use*
Stroke / drug therapy*,  immunology,  metabolism
Reg. No./Substance:
0/Inflammation Mediators; 0/Neuroprotective Agents; 0/Reactive Oxygen Species; 0/Stilbenes; Q369O8926L/resveratrol

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