| Therapeutic effects of potassium sodium hydrogen citrate on melamine-induced urinary calculi in China. | |
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MedLine Citation:
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PMID: 20529547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: In 2008, a sharp increase of the number of children diagnosed with urinary calculi was observed in China, 9433 children were diagnosed as having melamine-induced urinary calculi at outpatient clinic in Beijing Children's Hospital. This study examined the therapeutic efficacy of potassium sodium hydrogen citrate (PSHC) used to treat melamine-induced urinary stones in Chinese children who consumed melamine-containing infant formula. METHODS: Seventy-two infants and children (average age (18.2 +/- 7.7) months) who were diagnosed with urinary calculi were randomly divided into three treatment groups using the SAS Plan program. Group 1 was given a low dose (1 g/d) of PSHC, group 2 was given high dose of PSHC (2 g/d) and group 3 was given no PSHC (control group). The dose of drug was adjusted according to the baseline urinary pH. This study analyzed the influence of the dose of PSHC, the age of patients, stone size and position, and urinary pH on the level of efficacy of PSHC (cured, effectively treated or not cured). RESULTS: After 1 - 6 months of therapy, 19 patients from group 1, five patients from group 2 and six patients from group 3 were cured. Five patients from group 1, five patients from group 2 and four patients from group 3 were effectively treated. There were significant differences in therapeutic efficacy between the two treatment doses after 3 and 6 months as measured by the increase in the successful expulsion rate and time of melamine-induced urinary calculi. After 6 months the mean time of expulsion of urinary calculi in groups 1 and 2 was significantly shorter than in the control group. CONCLUSIONS: PSHC can significantly increase the successful expulsion rate and time of melamine-induced urinary calculi. The therapeutic efficacy is affected by PSHC dose, treatment duration, calculi position, and urinary pH. There is no relationship between the therapeutic efficacy and the stone size or patient age. |
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Authors:
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Jie Gao; Ying Shen; Ning Sun; Li-qun Jia; Yue-song Pan; Qiang Sun |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Chinese medical journal Volume: 123 ISSN: 0366-6999 ISO Abbreviation: Chin. Med. J. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-06-09 Completed Date: 2010-09-14 Revised Date: 2010-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7513795 Medline TA: Chin Med J (Engl) Country: China |
Other Details:
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Languages: eng Pagination: 1112-6 Citation Subset: IM |
Affiliation:
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Department of Nephrology, Beijing Children's Hospital Affiliated to Capital Medical University, Beijing 100045, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Child Child, Preschool China Citrates / therapeutic use* Female Humans Hydrogen-Ion Concentration Infant Infant, Newborn Male Middle Aged Treatment Outcome Triazines / toxicity* Urinary Calculi / chemically induced*, drug therapy*, urine Urine / chemistry Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Citrates; 0/Triazines; 108-78-1/melamine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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