Document Detail


Therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding.
MedLine Citation:
PMID:  23238778     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Aspiration pneumonia is an emerging problem in patients receiving gastrostomy feeding. This study is designed to clarify the therapeutic effects of mosapride citrate and lansoprazole for prevention of aspiration pneumonia in patients receiving gastrostomy feeding. METHODS: The study subjects were 119 patients with dysphasia who required gastrostomy feeding. They were randomly assigned to the control (without medication), lansoprazole (15 mg, 1/day), and mosapride (5 mg, 3/day) groups. The number of days with fever (≥37.8 °C), vomiting, and antibiotics administration, as well as the occurrence of pneumonia were investigated during the 6-month observation period. RESULTS: The incidence of pneumonia during the observation period was significantly lower in the mosapride group as compared to the control (7/38 vs. 16/40, p = 0.038) and lansoprazole (vs. 20/41, p = 0.005) groups. The mosapride group also showed a significant decrease in days with fever and antibiotics administration as compared to the other groups. Multivariate analysis revealed that the presence of hiatal hernia was a significant risk factor and administration of mosapride was a significant preventive factor for pneumonia. CONCLUSION: Mosapride has a preventive effect on occurrence of pneumonia in patients receiving gastrostomy feeding.
Authors:
Kento Takatori; Rihito Yoshida; Aya Horai; Shinya Satake; Takayuki Ose; Naoto Kitajima; Shushi Yoneda; Kyoichi Adachi; Yuji Amano; Yoshikazu Kinoshita
Related Documents :
16768188 - Surgical outcomes in correction of brown syndrome.
11465818 - Tracheoesophageal puncture in the office setting with local anesthesia.
12393038 - Voice outcome following thyroplasty in patients with longstanding vocal fold immobility.
12925818 - Fat augmentation following microsurgical removal of the vocal nodules: long-term results.
2106018 - The effectiveness of flumazenil in reversing the sedation and amnesia produced by intra...
23034688 - Prose treatment for lagophthalmos and exposure keratopathy.
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-12-13
Journal Detail:
Title:  Journal of gastroenterology     Volume:  -     ISSN:  1435-5922     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-12-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of Internal Medicine, Kasai City Hospital, 1-13 Yokoo, Houjou, Kasai-city, Hyogo, 675-2393, Japan, kent8t8@gmail.com.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Effects of local insulin delivery on subperiosteal angiogenesis and mineralized tissue formation dur...
Next Document:  A new scheme for sensitive detection of terahertz photons.