| Therapeutic effects of famotidine on chronic symptomatic gastritis: subgroup analysis from FUTURE study. | |
| | |
MedLine Citation:
|
PMID: 22183857 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
BACKGROUND: A therapeutic strategy for symptomatic patients with chronic gastritis has not been established. Gastric acid has been reported to induce a variety of unpleasant abdominal symptoms. We investigated whether the histamine H2 receptor antagonist famotidine attenuated upper abdominal symptoms in patients with chronic gastritis. METHODS: In this multicenter prospective single-arm open-label study, 10,311 patients with a clinical diagnosis of chronic symptomatic gastritis were enrolled and each patient was administered famotidine at 20 mg/day for 4 weeks. The intensity levels of upper abdominal symptoms, epigastralgia, epigastric fullness, and heartburn were evaluated using a face scale (grade 0-4). Abdominal symptom-related quality of life (QOL) impairment was also evaluated, using an Izumo scale before and after famotidine administration. In a subgroup analysis, symptomatic responses in patients diagnosed with functional dyspepsia (FD) according to the Rome III criteria were analyzed. RESULTS: In 8,460 patients who completed the protocol, famotidine administration significantly attenuated epigastralgia, epigastric fullness, and heartburn, and famotidine also attenuated abdominal symptom-related QOL impairment in all patients with chronic symptomatic gastritis, in those with FD-like symptoms without organic disease, and in those with FD as defined by the Rome III criteria. CONCLUSION: Famotidine is effective to relieve abdominal symptoms and improve QOL, not only in patients with Rome III-defined FD, but also in those with chronic symptomatic gastritis. |
| | |
Authors:
|
Yoshikazu Kinoshita; Tsutomu Chiba; |
Related Documents
:
|
6722017 - Digital vasculitis in patients with cryptogenic fibrosing alveolitis. 20693957 - Tgf-beta1 in bronchoalveolar lavage fluid in diffuse parenchymal lung diseases and high... 15009767 - Transcatheter coil closure of pulmonary arteriovenous malformations in children. 7539327 - Soluble form of p-selectin in plasma is elevated in acute lung injury. 15582137 - Referral of chronic hepatitis b patients from primary to specialist care: making a simp... 19957197 - Candidate gene analysis of semaphorins in patients with alzheimer's disease. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-21 |
Journal Detail:
|
Title: Journal of gastroenterology Volume: - ISSN: 1435-5922 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-20 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Izumo, Japan, kinosita@med.shimane-u.ac.jp. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: ROR?-induced activation of AMP-activated protein kinase results in attenuation of hepatic steatosis.
Next Document: Risk factors for pancreatic stone formation in autoimmune pancreatitis over a long-term course.