| Therapeutic effects of astragalus polysaccharides on inflammation and synovial apoptosis in rats with adjuvant-induced arthritis. | |
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MedLine Citation:
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PMID: 21199477 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Background: Rheumatoid arthritis (RA), an autoimmune disease, is characterized by pronounced inflammation and cell accumulation within affected joints. Beneficial effects of active ingredients of the astragalus root (Radix astrogali) in treatment of immunological diseases have been previously observed, but the mechanisms are not well understood. This study aims to evaluate therapeutic effects and the mechanisms of astragalus polysaccharides (APS) on adjuvant-induced arthritis (AA) in rats. Methods: Effects of treatment of AA rats with increasing doses of APS, Tripterygium glycosides (positive control) and saline (negative control) on swelling, arthritic index, synovial cell accumulation, serum concentrations of tumor necrosis factor α (TNF-α) and interleukin-1β (IL-1β), synovial apoptosis and immunostaining for Bcl-2 and Bax were determined. Results: APS treatment reduced cell accumulation, swelling and arthritic index of the joints and serum concentrations of TNF-α and IL1-β in a dose-dependent manner in AA rats. Synovial cell apoptosis was elevated in response to APS treatment and accompanied by increased staining for pro-apoptotic Bax protein and decreased staining for anti-apoptotic Bcl-2 protein. Conclusions: APS treatment reduced multiple indices of arthritis in rats with AA. Results support further investigation of therapeutic effects of APS in treatment of RA and other autoimmune diseases. |
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Authors:
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Jun-Bing Jiang; Jian-Dong Qiu; Li-Hua Yang; Jun-Ping He; George W Smith; Hong-Quan Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal of rheumatic diseases Volume: 13 ISSN: 1756-185X ISO Abbreviation: Int J Rheum Dis Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2011-01-04 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101474930 Medline TA: Int J Rheum Dis Country: England |
Other Details:
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Languages: eng Pagination: 396-405 Citation Subset: IM |
Copyright Information:
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© 2010 Asia Pacific League of Associations for Rheumatology and Blackwell Publishing Asia Pty Ltd. |
Affiliation:
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College of Veterinary Medicine and Animal Science, Shanxi Agricultural University, Taigu Quarantine Station for Animals, Taiyuan, Shanxi, China Laboratory of Mammalian Reproductive Biology and Genomics, Departments of Animal Science and Physiology, Michigan State University, East Lansing, Michigan MI 48824 USA. |
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