Document Detail

Therapeutic effect of transcatheter arterial chemoembolization on hepatocellular carcinoma: evaluation with contrast-enhanced harmonic power Doppler ultrasound.
MedLine Citation:
PMID:  11044926     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to investigate the usefulness of contrast-enhanced harmonic power Doppler ultrasound (US) for the detection of residual viable hepatocellular carcinoma (HCC) after treatment with transcatheter arterial chemoembolization (TACE). Forty-seven patients with 68 HCC lesions 1.8-9.5 cm in diameter (mean +/- SD 4.3 +/- 1.7 cm) underwent contrast-enhanced power Doppler US, in the harmonic mode, before and after treatment with TACE. Unenhanced spiral CT and contrast-enhanced dynamic MR imaging were also performed to help establish the outcome of therapy. Before treatment, intratumoral blood flow signals were detected at contrast-enhanced harmonic power Doppler US in 65 (95%) of 68 lesions. After TACE, flow signals were no longer detectable in 22 of these 65 lesions, which showed complete response at spiral CT and dynamic MR imaging. In 38 (88%) of the 43 lesions with partial response, intratumoral flow signals were still identified at contrast-enhanced harmonic power Doppler US. Twenty-eight of these 38 lesions underwent additional treatment with percutaneous ethanol injection (PEI) using contrast-enhanced harmonic power Doppler US guidance. Complete response was seen after PEI in 23 of 28 lesions. Contrast-enhanced harmonic power Doppler US proved useful for assessing the therapeutic effect of TACE on HCC and for guiding additional treatment with PEI in cases of partial response.
D Cioni; R Lencioni; C Bartolozzi
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Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article    
Journal Detail:
Title:  European radiology     Volume:  10     ISSN:  0938-7994     ISO Abbreviation:  Eur Radiol     Publication Date:  2000  
Date Detail:
Created Date:  2001-01-17     Completed Date:  2001-02-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9114774     Medline TA:  Eur Radiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1570-5     Citation Subset:  IM    
Department of Oncology, University of Pisa, Italy.
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MeSH Terms
Antineoplastic Combined Chemotherapy Protocols / administration & dosage*
Blood Flow Velocity
Carcinoma, Hepatocellular / blood supply,  therapy,  ultrasonography*
Catheterization, Peripheral*
Chemoembolization, Therapeutic / methods*
Contrast Media / administration & dosage*
Injections, Intra-Arterial
Injections, Intravenous
Liver Neoplasms / blood supply,  therapy,  ultrasonography*
Middle Aged
Polysaccharides / administration & dosage,  diagnostic use
Prospective Studies
Sensitivity and Specificity
Ultrasonography, Doppler, Color / methods*
Video Recording
Reg. No./Substance:
0/Contrast Media; 0/Polysaccharides; 127279-08-7/SHU 508

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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