Document Detail

Therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation in rats.
MedLine Citation:
PMID:  15769309     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To investigate the therapeutic effect of cisapride on gastric injury following hemorrhagic shock resuscitation. METHODS: 108 Wistar rats weighing (200 g+/-30 g) were randomly divided into a sham shock (SS) group (n=36), a hemorrhagic shock resuscitation (HS) group (n=36) and a hemorrhagic shock cisapride treated (HSC) group (n=36). Sampling at 1, 2 and 4 hours after resuscitation was done and 6 samples for each observation item were taken. The gastric blood flow volume was measured by isotope label biological microglobulin. Gastric pHi, gastric emptying, MDA and Na+-K+-ATPase of gastric mucosa were measured. RESULTS: In the HSC group, the relative residual rate of gastric pigment decreased significantly, the gastric blood flow volume elevated; gastric pHi increased significantly at 2 hours; the level of mucosal MDA decreased at 4 hours, the activity of Na+-K+-ATPase increased and the lactic acid level in the portal vein decreased significantly compared to the HS group. CONCLUSIONS: After hemorrhagic shock resuscitation, cisapride contained the following functions, 1) promoting gastric emptying, 2) increasing the blood flow of gastric blood flow volume and gastric pHi, 3) depressing the lactic acid concentration of the portal vein and improving MDA volume and Na+-K+-ATPase activity of gastric mucosa. It suggests that after complementing effective circulating blood volume for hemorrhagic shock resuscitation, early use of cisapride for gastric motility is helpful for an improvement of lasting ischemia and hypoxia in stomach.
Lian-yang Zhang; Zheng-guo Wang; Pei-fang Zhu; Yan Xu
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Chinese journal of traumatology = Zhonghua chuang shang za zhi / Chinese Medical Association     Volume:  8     ISSN:  1008-1275     ISO Abbreviation:  Chin. J. Traumatol.     Publication Date:  2005 Apr 
Date Detail:
Created Date:  2005-03-16     Completed Date:  2005-07-05     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  100886162     Medline TA:  Chin J Traumatol     Country:  China    
Other Details:
Languages:  eng     Pagination:  101-4     Citation Subset:  IM    
General Surgery Department, Daping Hospital, Research Institute of Field Surgery, Third Military Medical University, Chongqing 400042, China.
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MeSH Terms
Cisapride / therapeutic use*
Disease Models, Animal
Gastric Emptying / drug effects
Gastric Mucosa / chemistry,  enzymology
Gastrointestinal Agents / therapeutic use*
Hydrogen-Ion Concentration / drug effects
Rats, Wistar
Regional Blood Flow / drug effects
Shock, Hemorrhagic / complications*,  therapy*
Sodium-Potassium-Exchanging ATPase / metabolism
Stomach / blood supply,  pathology
Stomach Diseases / drug therapy*,  etiology*
Reg. No./Substance:
0/Gastrointestinal Agents; 81098-60-4/Cisapride; EC ATPase

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