Document Detail

Therapeutic effect of SF-2103A, a novel carbapenem antibiotic, in combination with cefotaxime, cefoperazone and other cephalosporins.
MedLine Citation:
PMID:  3531130     Owner:  NLM     Status:  MEDLINE    
Combinations of SF-2103A with cefotaxime, cefoperazone or cefazolin showed synergistic efficacy at a wide range of combination ratios against experimental infection in mice due to Proteus vulgaris GN76/C-1, producing type Ic cephalosporinase, Escherichia coli No. 29/36 RGN823, producing type IIIa (TEM-2) penicillinase and E. coli GN206, producing type Ib cephalosporinase. These effects by SF-2103A were greater than those seen with sulbactam. The in vitro and in vivo synergistic activities were roughly correlated. Potent in vivo activity of SF-2103A was related to good pharmacokinetic properties, with blood half-life of 30 minutes and urinary recovery of 55.2% after parenteral administration to rats. Furthermore, SF-2103A was stable to rat kidney homogenate. The high stability of SF-2103A in aqueous and biological media was correlated with the sulfonate group at C-3.
T Yoshida; Y Kazuno; T Shomura; S Murata; S Inouye; T Ito
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of antibiotics     Volume:  39     ISSN:  0021-8820     ISO Abbreviation:  J. Antibiot.     Publication Date:  1986 Jul 
Date Detail:
Created Date:  1986-10-30     Completed Date:  1986-10-30     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0151115     Medline TA:  J Antibiot (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  956-65     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*,  metabolism
Cefoperazone / administration & dosage*
Cefotaxime / administration & dosage*
Cephalosporins / administration & dosage*,  metabolism
Drug Stability
Drug Synergism
Drug Therapy, Combination
Escherichia coli Infections / drug therapy
Proteus Infections / drug therapy
Rats, Inbred Strains
Structure-Activity Relationship
beta-Lactamases / antagonists & inhibitors*
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Carbapenems; 0/Cephalosporins; 62893-19-0/Cefoperazone; 63527-52-6/Cefotaxime; 82138-64-5/pluracidomycin; EC

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