Document Detail

Therapeutic digoxin level in chylous drainage with no detectable plasma digoxin level.
MedLine Citation:
PMID:  9824036     Owner:  NLM     Status:  MEDLINE    
A patient receiving digoxin for long-standing congestive heart failure developed a chylothorax following removal of an infected aortic graft. Drainage of the chylothorax resulted in plasma digoxin concentrations which were near zero while the digoxin levels in the chylous drainage fluid were therapeutic. The sequestration of even low lipid-soluble drugs, such as digoxin, in chyle should be recognized to prevent subtherapeutic plasma levels in patients undergoing chylothorax drainage.
M D Taylor; S S Kim; L J Vaias
Related Documents :
1522706 - Comparative kinetics of digoxin in serum and vitreous humor in a guinea pig model. ii. ...
3921586 - Pharmacokinetics, bioavailability and serum levels of cardiac glycosides.
709776 - Relationship between plasma concentration and dose of digoxin in patients with and with...
25342066 - In vivo detection of fluctuating brain steroid levels in zebra finches.
2424076 - Evaluation of a radioimmunoassay for cholecystokinin in human plasma.
197116 - Distribution of antibody to hepatitis a antigen in a population of commerical plasma do...
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  114     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-09     Completed Date:  1998-12-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1482-4     Citation Subset:  AIM; IM    
Long Beach Veterans Administration Hospital, Department of Surgery, CA 90822, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cardiotonic Agents / blood*,  therapeutic use*
Chyle / chemistry
Chylothorax / complications,  metabolism*,  therapy
Digoxin / analysis,  blood*,  therapeutic use*
Heart Failure / blood,  drug therapy
Reg. No./Substance:
0/Cardiotonic Agents; 20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Aspiration pneumonia secondary to giant cervical osteophyte formation (diffuse idiopathic skeletal h...
Next Document:  Necrotizing myocardial vasculitis in Churg-Strauss syndrome: clinicohistologic evaluation of steroid...