Document Detail


Therapeutic digoxin level in chylous drainage with no detectable plasma digoxin level.
MedLine Citation:
PMID:  9824036     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A patient receiving digoxin for long-standing congestive heart failure developed a chylothorax following removal of an infected aortic graft. Drainage of the chylothorax resulted in plasma digoxin concentrations which were near zero while the digoxin levels in the chylous drainage fluid were therapeutic. The sequestration of even low lipid-soluble drugs, such as digoxin, in chyle should be recognized to prevent subtherapeutic plasma levels in patients undergoing chylothorax drainage.
Authors:
M D Taylor; S S Kim; L J Vaias
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Chest     Volume:  114     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  1998 Nov 
Date Detail:
Created Date:  1998-12-09     Completed Date:  1998-12-09     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1482-4     Citation Subset:  AIM; IM    
Affiliation:
Long Beach Veterans Administration Hospital, Department of Surgery, CA 90822, USA.
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MeSH Terms
Descriptor/Qualifier:
Aged
Cardiotonic Agents / blood*,  therapeutic use*
Chyle / chemistry
Chylothorax / complications,  metabolism*,  therapy
Digoxin / analysis,  blood*,  therapeutic use*
Drainage
Heart Failure / blood,  drug therapy
Humans
Male
Chemical
Reg. No./Substance:
0/Cardiotonic Agents; 20830-75-5/Digoxin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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