| Therapeutic considerations for disease progression in multiple sclerosis: evidence, experience, and future expectations. | |
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MedLine Citation:
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PMID: 16216934 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the management of patients with multiple sclerosis (MS), providers are all faced with the highly formidable challenge of ascertaining whether, and to what degree, disease-modifying therapy is effective in the individual patient. While much has been learned in randomized, controlled clinical trials, we cannot simply extrapolate the outcomes of these initiatives and apply them to the care of a single patient. In the future, the application of pharmacogenetic techniques, proteomics, and microarray analysis will yield novel profiling information on individual patients that will substantially refine the specific therapeutic questions of relevance: (1) What is the best treatment for an individual patient? (2) Which patients require intensive therapeutic combination regimens to optimize control of the disease process? (3) What are the appropriate drug dosing targets for an individual patient? and (4) Which patients will be predisposed to the development of drug-related adverse events? Such data may provide a novel variable of drug responsiveness that will mandate its inclusion into the process of covariate analyses for clinical trials. |
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Authors:
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Elliot M Frohman; Olaf Stüve; Eva Havrdova; John Corboy; Anat Achiron; Robert Zivadinov; Per Soelberg Sorensen; J Theodore Phillips; Brian Weinshenker; Kathleen Hawker; Hans-Peter Hartung; Lawrence Steinman; Scott Zamvil; Bruce A C Cree; Stephen Hauser; Howard Weiner; Michael K Racke; Massimo Filippi |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Archives of neurology Volume: 62 ISSN: 0003-9942 ISO Abbreviation: Arch. Neurol. Publication Date: 2005 Oct |
Date Detail:
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Created Date: 2005-10-11 Completed Date: 2005-11-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372436 Medline TA: Arch Neurol Country: United States |
Other Details:
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Languages: eng Pagination: 1519-30 Citation Subset: AIM; IM |
Affiliation:
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Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. elliot.frohman@utsouthwestern.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Disease Progression Humans Multiple Sclerosis / therapy* Randomized Controlled Trials as Topic |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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