Document Detail


Therapeutic basis of glycyrrhizin on chronic hepatitis B.
MedLine Citation:
PMID:  8783808     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Glycyrrhizin, a major component of a herb (licorice), has been intravenously used for the treatment of chronic hepatitis B in Japan and improves liver function with occasional complete recovery from hepatitis. This substance modifies the intracellular transport and suppresses sialylation of hepatitis B virus (HBV) surface antigen (HBsAg) in vitro. This study was designed to clarify the pharmacological basis for its effectiveness. The structure-bioactivity relationship of glycyrrhizin, glycyrrhetic acid 3-O-monoglucuronide and glycyrrhetic acid was determined, and glycyrrhetic acid was found to be the most active of them. The amounts of three substances bound to the liver were evaluated in guinea pigs after intravenous administration of glycyrrhizin. Glycyrrhizin and glycyrrhetic acid 3-O-monoglucuronide were detected at concentrations of 31.8-1.3 micrograms/g of liver, but glycyrrhetic acid was not detected. When glycyrrhizin attained these concentrations in the cellular fraction of the PLC/PRF/5 cell culture, it suppressed the secretion of HBsAg as reported previously. These results indicated that glycyrrhizin administered intravenously might bind to hepatocytes at the concentration at which glycyrrhizin could modify the expression of HBV-related antigens on the hepatocytes and suppress sialylation of HBsAg.
Authors:
H Sato; W Goto; J Yamamura; M Kurokawa; S Kageyama; T Takahara; A Watanabe; K Shiraki
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Antiviral research     Volume:  30     ISSN:  0166-3542     ISO Abbreviation:  Antiviral Res.     Publication Date:  1996 May 
Date Detail:
Created Date:  1997-05-02     Completed Date:  1997-05-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8109699     Medline TA:  Antiviral Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  171-7     Citation Subset:  IM    
Affiliation:
Department of Virology, Toyama Medical and Pharmaceutical University, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Antiviral Agents / chemistry,  metabolism,  pharmacology*
Glycyrrhetinic Acid / analogs & derivatives*,  chemistry,  metabolism,  pharmacology
Glycyrrhizic Acid
Guinea Pigs
Hepatitis B Surface Antigens / metabolism
Hepatitis B virus / drug effects*
Humans
Liver / metabolism
Molecular Structure
Tumor Cells, Cultured
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Hepatitis B Surface Antigens; 1405-86-3/Glycyrrhizic Acid; 471-53-4/Glycyrrhetinic Acid

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