| Therapeutic approaches to reflux disease, focusing on acid secretion. | |
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MedLine Citation:
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PMID: 12698865 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Gastroesophageal reflux disease (GERD) is caused by a combination of esophageal motor dysfunction accompanied by maintained gastric acid secretion. Noninvasive medical treatment of GERD is mainly provided by inhibiting gastric acid secretion, because this is easier than restoring esophageal motor function by administration of drugs. Proton pump inhibitors (PPIs) and histamine H2 receptor antagonists (H2RAs) are two major acid-suppressing drugs used for the treatment of GERD. PPIs have better characteristics for the long-term treatment of GERD, because they have a long-lasting, strong effect of raising intragastric pH and have no tachyphylaxis/tolerance phenomena on repeated dosing. Some patients with Helicobacter pylori-negative high-grade GERD may show nocturnal decreases in pH during treatment with PPIs and resistance to treatment with PPI. For these patients, addition of H2RAs to PPIs can be useful for controlling GERD, at least for short-term treatment. For long-term control of such cases, further studies are necessary. |
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Authors:
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Yoshikazu Kinoshita; Kyoichi Adachi; Hirofumi Fujishiro |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Journal of gastroenterology Volume: 38 Suppl 15 ISSN: 0944-1174 ISO Abbreviation: J. Gastroenterol. Publication Date: 2003 Mar |
Date Detail:
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Created Date: 2003-04-17 Completed Date: 2003-07-02 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 9430794 Medline TA: J Gastroenterol Country: Japan |
Other Details:
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Languages: eng Pagination: 13-9 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine II, Shimane Medical University, 89-1 Enya-cho, Izumo 693-8501, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Antacids
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therapeutic use* Gastric Acid / secretion* Gastroesophageal Reflux / drug therapy*, physiopathology Histamine H2 Antagonists / therapeutic use* Humans Proton Pumps / antagonists & inhibitors*, therapeutic use* Time Factors Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antacids; 0/Histamine H2 Antagonists; 0/Proton Pumps |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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