Document Detail

Therapeutic approaches to reflux disease, focusing on acid secretion.
MedLine Citation:
PMID:  12698865     Owner:  NLM     Status:  MEDLINE    
Gastroesophageal reflux disease (GERD) is caused by a combination of esophageal motor dysfunction accompanied by maintained gastric acid secretion. Noninvasive medical treatment of GERD is mainly provided by inhibiting gastric acid secretion, because this is easier than restoring esophageal motor function by administration of drugs. Proton pump inhibitors (PPIs) and histamine H2 receptor antagonists (H2RAs) are two major acid-suppressing drugs used for the treatment of GERD. PPIs have better characteristics for the long-term treatment of GERD, because they have a long-lasting, strong effect of raising intragastric pH and have no tachyphylaxis/tolerance phenomena on repeated dosing. Some patients with Helicobacter pylori-negative high-grade GERD may show nocturnal decreases in pH during treatment with PPIs and resistance to treatment with PPI. For these patients, addition of H2RAs to PPIs can be useful for controlling GERD, at least for short-term treatment. For long-term control of such cases, further studies are necessary.
Yoshikazu Kinoshita; Kyoichi Adachi; Hirofumi Fujishiro
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  38 Suppl 15     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  2003 Mar 
Date Detail:
Created Date:  2003-04-17     Completed Date:  2003-07-02     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  13-9     Citation Subset:  IM    
Department of Internal Medicine II, Shimane Medical University, 89-1 Enya-cho, Izumo 693-8501, Japan.
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MeSH Terms
Antacids / therapeutic use*
Gastric Acid / secretion*
Gastroesophageal Reflux / drug therapy*,  physiopathology
Histamine H2 Antagonists / therapeutic use*
Proton Pumps / antagonists & inhibitors*,  therapeutic use*
Time Factors
Treatment Outcome
Reg. No./Substance:
0/Antacids; 0/Histamine H2 Antagonists; 0/Proton Pumps

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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