Document Detail


Therapeutic applications of ribozymes and riboswitches.
MedLine Citation:
PMID:  20685165     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Therapeutic approaches employing RNA as a tool or as a drug target have recently emerged and have been employed for various applications-ranging from cancer treatment to virus infection. Despite the paucity of its molecular groups compared to proteins, RNA has nevertheless proved to be an excellent choice for researchers who have aspired to develop therapeutic tools. Ribozymes and riboswitches are RNA-based therapeutic tools that are most often employed to knockdown gene expression and to inhibit bacterial infections, respectively. The aim of this review is to summarize recent advances observed in ribozyme- and riboswitch-based therapeutic applications that, in some cases, have reached clinical trials.
Authors:
Jérôme Mulhbacher; Patrick St-Pierre; Daniel A Lafontaine
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-03
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  10     ISSN:  1471-4973     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  551-6     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.
Affiliation:
Groupe ARN/RNA Group, Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1.
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MeSH Terms
Descriptor/Qualifier:
Gene Knockdown Techniques
Gene Therapy
HIV Infections / genetics,  therapy
Humans
Neoplasms / genetics,  therapy
Prion Diseases / genetics,  therapy
RNA, Catalytic / genetics,  therapeutic use*
Riboswitch / physiology*
Grant Support
ID/Acronym/Agency:
//Canadian Institutes of Health Research
Chemical
Reg. No./Substance:
0/RNA, Catalytic; 0/Riboswitch; 0/hammerhead ribozyme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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