Document Detail

Therapeutic applications of ribozymes and riboswitches.
MedLine Citation:
PMID:  20685165     Owner:  NLM     Status:  MEDLINE    
Therapeutic approaches employing RNA as a tool or as a drug target have recently emerged and have been employed for various applications-ranging from cancer treatment to virus infection. Despite the paucity of its molecular groups compared to proteins, RNA has nevertheless proved to be an excellent choice for researchers who have aspired to develop therapeutic tools. Ribozymes and riboswitches are RNA-based therapeutic tools that are most often employed to knockdown gene expression and to inhibit bacterial infections, respectively. The aim of this review is to summarize recent advances observed in ribozyme- and riboswitch-based therapeutic applications that, in some cases, have reached clinical trials.
Jérôme Mulhbacher; Patrick St-Pierre; Daniel A Lafontaine
Related Documents :
1679825 - The role of barrier precautions in infection control.
19665925 - Campylobacter jejuni: a brief overview on pathogenicity-associated factors and disease-...
7943995 - Common variable immunodeficiency: diagnosis and management.
25037735 - Multidrug resistant acinetobacter baumannii reaches a new frontier: prosthetic hip join...
24421915 - Nodule worm infection in humans and wild primates in uganda: cryptic species in a newly...
7231925 - Isolation of anaplasma marginale from rhipicephalus simus males.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-08-03
Journal Detail:
Title:  Current opinion in pharmacology     Volume:  10     ISSN:  1471-4973     ISO Abbreviation:  Curr Opin Pharmacol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-09-20     Completed Date:  2011-01-05     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100966133     Medline TA:  Curr Opin Pharmacol     Country:  England    
Other Details:
Languages:  eng     Pagination:  551-6     Citation Subset:  IM    
Copyright Information:
Crown Copyright © 2010. Published by Elsevier Ltd. All rights reserved.
Groupe ARN/RNA Group, Département de biologie, Faculté des sciences, Université de Sherbrooke, Sherbrooke, Québec, Canada J1K 2R1.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Gene Knockdown Techniques
Gene Therapy
HIV Infections / genetics,  therapy
Neoplasms / genetics,  therapy
Prion Diseases / genetics,  therapy
RNA, Catalytic / genetics,  therapeutic use*
Riboswitch / physiology*
Grant Support
//Canadian Institutes of Health Research
Reg. No./Substance:
0/RNA, Catalytic; 0/Riboswitch; 0/hammerhead ribozyme

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Immediate versus delayed self-reporting of symptoms and side effects during chemotherapy: Does timin...
Next Document:  Pre-transplant manipulation processing of umbilical cord blood units: Efficacy of Rubinstein's thawi...