| Therapeutic applications of nucleic acids as ligands for Toll-like receptors. | |
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MedLine Citation:
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PMID: 19330719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Intracellular TLRs, represented by TLRs 3, 7, 8 and 9, are specialized for the recognition of different types of microbe-derived nucleic acids. However, endogenous nucleic acids can also activate these TLRs, triggering autoimmunity. Nucleic acid-sensing TLRs initiate innate immune responses upon infection, but these receptors also initiate the development of protective adaptive immune responses. Therefore, TLR stimulation represents an attractive strategy for the development of therapeutic and prophylactic agents targeting microbial infections, cancers and allergies. The current use of stimulatory nucleic acids targeting TLRs is reviewed for applications ranging from vaccine adjuvants to anticancer, antiviral and anti-allergic agents. In addition, inhibitory nucleic acid ligands being evaluated for their ability to ameliorate autoimmune disorders and viremias, such as systemic lupus erythematosus and HIV infection, respectively, are described. |
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Authors:
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Gabriela Panter; Alenka Kuznik; Roman Jerala |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review |
Journal Detail:
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Title: Current opinion in molecular therapeutics Volume: 11 ISSN: 2040-3445 ISO Abbreviation: Curr. Opin. Mol. Ther. Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-06-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100891485 Medline TA: Curr Opin Mol Ther Country: England |
Other Details:
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Languages: eng Pagination: 133-45 Citation Subset: IM |
Affiliation:
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Faculty of Chemistry and Chemical Technology, University of Ljubljana, Hajdrihova 19, Ljubljana, Slovenia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adjuvants, Immunologic
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therapeutic use* Animals Anti-Allergic Agents / immunology*, therapeutic use Autoimmune Diseases / drug therapy*, immunology Autoimmunity / immunology Humans Models, Biological Nucleic Acids / immunology, therapeutic use* Toll-Like Receptors / agonists*, immunology*, metabolism |
| Chemical | |
Reg. No./Substance:
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0/Adjuvants, Immunologic; 0/Anti-Allergic Agents; 0/Nucleic Acids; 0/Toll-Like Receptors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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