| Therapeutic applications of macrophage colony-stimulating factor (CSF-1) and antagonists of CSF-1 receptor (CSF-1R) signaling. | |
| | |
MedLine Citation:
|
PMID: 22186992 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Macrophage-colony stimulating factor (CSF-1) signaling through its receptor (CSF-1R) promotes the differentiation of myeloid progenitors into heterogeneous populations of monocytes, macrophages, dendritic cells and bone-resorbing osteoclasts. In the periphery, CSF-1 regulates the migration, proliferation, function and survival of macrophages which function at multiple levels within the innate and adaptive immune systems. Macrophage populations elicited by CSF-1 are associated with, and exacerbate, a broad spectrum of pathologies including cancer, inflammation and bone disease. Conversely, macrophages can also contribute to immunosuppression, disease resolution and tissue repair. Recombinant CSF-1, antibodies against the ligand and the receptor, and specific inhibitors of CSF-1R kinase activity have been each been tested in a range of animal models and in some cases, in patients. This review examines the potential clinical uses of modulators of the CSF-1/CSF-1R system. We conclude that CSF-1 promotes a resident-type macrophage phenotype. As a treatment, CSF-1 has therapeutic potential in tissue repair. Conversely, inhibition of CSF-1R is unlikely to be effective in inflammatory disease but may have utility in cancer. |
| | |
Authors:
|
David A Hume; Kelli P Macdonald |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-12-20 |
Journal Detail:
|
Title: Blood Volume: - ISSN: 1528-0020 ISO Abbreviation: - Publication Date: 2011 Dec |
Date Detail:
|
Created Date: 2011-12-21 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7603509 Medline TA: Blood Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, United Kingdom; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Paradoxical absence of a prothrombotic phenotype in a mouse model of severe hyperhomocysteinemia.
Next Document: Targeting CXCR4 with cell-penetrating pepducins in lymphoma and lymphocytic leukemia.