Document Detail


Therapeutic apheresis in the Republic of Macedonia - our five years experience (2000-2004).
MedLine Citation:
PMID:  16862064     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Membrane plasma exchange (PE) is a mode of extracorporeal blood purification. Since 1985 membrane PE has been in regular use at the Department of Nephrology, Medical Faculty of Skopje, R.Macedonia. In this paper we report on five years (2000-2004) of single centre plasma exchange activity. We performed 540 PE treatments (108 PE/per year) on 99 patients. The M/F ratio was 40/48. The patients underwent a median of 5.45 procedures (range, 1-16). The treated patients were from different Departments. Protocols for PE depend on the disease and its severity. PE were performed 2-4 times weekly using Gambro PF 2000 N filters with an adaptation of the Gambro AK10 dialysis machine or with the Gambro Prizma machine (2 cases). Blood access was achieved through femoral vein. Substitution was made with fresh frozen plasma and/or with 20% human albumin combined with Ringer's solution. An average amount of 2150 ml plasmafiltrate per treatment (respectively 30 to 40 ml plasmafiltrate/kg body weight) was eliminated. Most therapeutic procedures were performed on patients from the Department of Neurology. 63.6% of all patients were referred for Myasthenia gravis and the Guillian Barre syndrome. The total number of procedures per year has remained fairly stable, corresponding to a median of 5.4 treatments/100 000 inhabitants. We observed hypocalcaemia in 8% of the patients, urticarial reactions in 7.3%, pruritic reactions in 12%, and hypotension/headache in 6.8%. No major procedural complications were seen.
Authors:
M Milovanceva-Popovska; Lj Stojkovski; L Grcevska; S Dzikova; V Ristovska; L Gogovska; M Polenakovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prilozi / Makedonska akademija na naukite i umetnostite, Oddelenie za biološki i medicinski nauki = Contributions / Macedonian Academy of Sciences and Arts, Section of Biological and Medical Sciences     Volume:  27     ISSN:  0351-3254     ISO Abbreviation:  Prilozi     Publication Date:  2006 Jul 
Date Detail:
Created Date:  2006-07-24     Completed Date:  2007-03-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101189513     Medline TA:  Prilozi     Country:  Macedonia    
Other Details:
Languages:  eng     Pagination:  37-44     Citation Subset:  IM    
Affiliation:
Department of Nephrology, Medical Faculty, Ss. Cyril and Methodius University, Skopje, R. Macedonia. majamil@freemail.com.mk
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MeSH Terms
Descriptor/Qualifier:
Guillain-Barre Syndrome / therapy
Humans
Myasthenia Gravis / therapy
Plasma Exchange* / methods,  statistics & numerical data

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