Document Detail


Therapeutic antibodies against viral hepatitis.
MedLine Citation:
PMID:  12772504     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Antibodies have the potential to be immunotherapeutic agents, used either as stand-alone therapy or as an adjunct for managing chronic viral infection. In addition, antibodies may be used prophylactically in individuals who have been accidentally exposed to hepatitis B virus (HBV) or hepatitis C virus (HCV), or to prevent re-infection of the liver in patients who have undergone liver transplantation. Human monoclonal antibodies to HBV and HCV were generated and their ability to reduce viral load was tested in different animal model systems, the Trimera mouse model and HBV-carrier chimpanzees. These antibodies were further developed and are currently being studied in clinical trials for chronic HBV or HCV and in liver transplant patients. The antibodies were shown to be safe, tolerable and could significantly reduce viral load. Their ability to inhibit HCV re-infection in the transplanted liver is being evaluated.
Authors:
Shlomo Dagan; Rachel Eren
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Current opinion in molecular therapeutics     Volume:  5     ISSN:  1464-8431     ISO Abbreviation:  Curr. Opin. Mol. Ther.     Publication Date:  2003 Apr 
Date Detail:
Created Date:  2003-05-29     Completed Date:  2003-07-28     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  100891485     Medline TA:  Curr Opin Mol Ther     Country:  England    
Other Details:
Languages:  eng     Pagination:  148-55     Citation Subset:  IM    
Affiliation:
XTL Biopharmaceuticals Ltd., Kiryat Weizmann Science Park, Rehovot 76100, Israel. sdagan@xtlbio.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antibodies, Monoclonal / immunology*,  therapeutic use*
Hepatitis Antibodies / immunology*,  therapeutic use*
Hepatitis B / immunology,  therapy*
Hepatitis C / immunology,  therapy*
Humans
Immunotherapy*
Mice
Pan troglodytes
Chemical
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/Hepatitis Antibodies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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