Document Detail

Therapeutic angiogenesis for critical limb ischemia: invited commentary.
MedLine Citation:
PMID:  11772469     Owner:  NLM     Status:  MEDLINE    
Lower extremity arterial occlusive disease results in tissue ischemia of the legs and is relatively common in the elderly. Clinically, it may be asymptomatic, cause muscle pain during exercise, or progress to a severe degree of ischemia that may result in limb loss. Although bypass surgery and angioplasty have increased the rate of limb salvage in these patients, amputation of the affected limb remains a common outcome for many patients. Therapeutic angiogenesis is the administration of angiogenic factors, or genes encoding these factors, to promote neovascularization and thereby increase blood flow to the ischemic leg. We have developed an animal model of hindlimb ischemia in which to study therapeutic angiogenesis. We chose nitric oxide as the angiogenic factor for our experiments because of its ability to induce angiogenesis, vasodilation, and inhibit inflammation. In this review, we will discuss our experience with our model of hindlimb ischemia, as well as discuss our results of gene therapy for therapeutic angiogenesis using nitric oxide.
Louis M Messina; Lucy S Brevetti; David S Chang; Robert Paek; Rajabrata Sarkar
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of controlled release : official journal of the Controlled Release Society     Volume:  78     ISSN:  0168-3659     ISO Abbreviation:  J Control Release     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2002-01-04     Completed Date:  2002-02-28     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8607908     Medline TA:  J Control Release     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  285-94     Citation Subset:  IM    
Division of Vascular Surgery, Department of Surgery, University of California at San Francisco M-488, 505 Parnassus Avenue, San Francisco, CA 94143-0222, USA.
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MeSH Terms
Adenoviridae / genetics
Extremities / blood supply*
Gene Therapy*
Gene Transfer, Horizontal
Ischemia / therapy*
Neovascularization, Physiologic*
Nitric Oxide / physiology
Nitric Oxide Synthase / genetics*
Nitric Oxide Synthase Type III
Regional Blood Flow
Grant Support
Reg. No./Substance:
10102-43-9/Nitric Oxide; EC protein, human; EC Oxide Synthase; EC Oxide Synthase Type III

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