Document Detail

Therapeutic amnioinfusions and fetal fibronectin pattern in a case with preterm ruptured membranes that resealed.
MedLine Citation:
PMID:  9650648     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: Determination of fetal fibronectin (fFN) levels in a patient at risk of preterm delivery and having premature rupture of the membranes. PATIENT AND METHODS: The present case report concerns a pregnant woman with premature rupture of the membranes at 16 weeks of gestation who was submitted to repeated therapeutic transabdominal amnioinfusions and had a spontaneous resolution of the rupture at 32 weeks of gestation. RESULTS: A good pregnancy outcome was observed. High cervicovaginal fFN levels were observed during the period of membrane rupture with following drop of fFN levels during this period and spontaneous reseal of the membranes. CONCLUSIONS: Active expectant management, using repeated amnioinfusions, probably played a useful role in the therapeutic success of this pregnancy. Further, fFN was a reliable marker of the rupture of membranes. The possible role of fFN in the clinical management of high-risk pregnancies is confirmed.
S De Carolis; B Carducci; L De Santis; S Ferrazzani; G Noia; A Merola; A Caruso
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Fetal diagnosis and therapy     Volume:  13     ISSN:  1015-3837     ISO Abbreviation:  Fetal. Diagn. Ther.     Publication Date:    1998 Mar-Apr
Date Detail:
Created Date:  1998-08-28     Completed Date:  1998-08-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9107463     Medline TA:  Fetal Diagn Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  66-8     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Catholic University of Rome, Italy.
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MeSH Terms
Fetal Membranes, Premature Rupture / therapy*
Fetus / metabolism*
Fibronectins / metabolism*
Gestational Age
Pregnancy Outcome*
Sodium Chloride / administration & dosage*
Reg. No./Substance:
0/Fibronectins; 0/Solutions; 7647-14-5/Sodium Chloride

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