Document Detail

Therapeutic alternatives for chronic urticaria: an evidence-based review, part 1.
MedLine Citation:
PMID:  18517070     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To evaluate the use of alternative therapies for chronic urticaria refractory to first-line treatments in an evidence-based manner. DATA SOURCES: MEDLINE searches were performed cross-referencing urticaria with the names of multiple therapies. Articles were then reviewed for additional citations. Articles published after 1950 were considered. STUDY SELECTION: All articles, including case reports, were reviewed for soundness and relevance. RESULTS: Experience has been reported for a wide variety of alternative therapies in the treatment of chronic idiopathic and physical urticarias. Evidence for most agents is limited to anecdotal reports. The second-line therapies reviewed are also categorized based on criteria of safety, efficacy, convenience, and cost, in relation to the first-line antihistamines. CONCLUSIONS: Alternative agents should be considered in patients with chronic urticaria who are both severely affected and unresponsive to antihistamines. Although monitoring for toxicity is important in management with many alternative agents, safety is favorable compared with corticosteroids.
Matt Morgan; David A Khan
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology     Volume:  100     ISSN:  1081-1206     ISO Abbreviation:  Ann. Allergy Asthma Immunol.     Publication Date:  2008 May 
Date Detail:
Created Date:  2008-06-03     Completed Date:  2008-07-02     Revised Date:  2009-01-29    
Medline Journal Info:
Nlm Unique ID:  9503580     Medline TA:  Ann Allergy Asthma Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  403-11; quiz 412-4, 468     Citation Subset:  IM    
Division of Allergy & Immunology, University of Texas Southwestern, Dallas, Texas 75390-8859, USA.
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MeSH Terms
Calcineurin / antagonists & inhibitors
Chloroquine / adverse effects,  therapeutic use
Colchicine / adverse effects,  therapeutic use
Histamine Antagonists / therapeutic use
Leukotriene Antagonists / adverse effects,  therapeutic use
Mycophenolic Acid / therapeutic use
Prednisone / adverse effects,  therapeutic use
Sulfones / adverse effects,  therapeutic use
Urticaria / drug therapy*
Reg. No./Substance:
0/Histamine Antagonists; 0/Leukotriene Antagonists; 0/Sulfones; 24280-93-1/Mycophenolic Acid; 53-03-2/Prednisone; 54-05-7/Chloroquine; 64-86-8/Colchicine; EC
Comment In:
Ann Allergy Asthma Immunol. 2008 Dec;101(6):647   [PMID:  19119713 ]
Ann Allergy Asthma Immunol. 2008 Nov;101(5):555; author reply 555-6   [PMID:  19055215 ]

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