Document Detail

Therapeutic advances in neurodegeneration with brain iron accumulation.
MedLine Citation:
PMID:  24209438     Owner:  NLM     Status:  In-Data-Review    
Neurodegeneration with brain iron accumulation (NBIA) includes a heterogeneous group of genetically defined progressive disorders with iron accumulation in the basal ganglia. Current conventional medical or surgical therapeutic options for these disorders remain unsatisfactory and do not prevent the disease to progress to a severe and most disabling condition for the patients. In the last decade, research has been focused on the role of iron in the pathophysiological process of these disorders. The availability of chelating agents with specific properties that have been demonstrated to be effective in other disorders with regional iron accumulation and MR techniques that allow a quantitative assessment of iron have very recently brought an increasing interest in the possible efficacy of chelating agents in NBIA, and preliminary results of pilot trials are now available. This chapter aims to provide an overview of the results of conventional medical and surgical treatments as well as of more innovative therapy in NBIA.
Giovanna Zorzi; Nardo Nardocci
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International review of neurobiology     Volume:  110     ISSN:  0074-7742     ISO Abbreviation:  Int. Rev. Neurobiol.     Publication Date:  2013  
Date Detail:
Created Date:  2013-11-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374740     Medline TA:  Int Rev Neurobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  153-64     Citation Subset:  IM    
Copyright Information:
© 2013 Elsevier Inc. All rights reserved.
Department of Child Neurology, Fondazione IRCCS Istituto Neurologico "Carlo Besta", Milan, Italy.
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