Document Detail

Therapeutic action of physical exercise on markers of oxidative stress induced by chronic kidney disease.
MedLine Citation:
PMID:  22771699     Owner:  NLM     Status:  Publisher    
AIM: To investigate the effects physical training exerts on markers of oxidative stress in rats with chronic kidney disease (CKD). MAIN METHODS: Twenty-four male Wistar rats were divided into four groups (n=6): sham, CKD, exercise-sham and exercise-CKD. Surgical reduction of the renal mass was performed (5/6 nephrectomized) and exercise was conducted on a treadmill (50min/day up to 1km/h for, 5days/week for eight weeks). Forty-eight hours after the last exercise session, blood (1mL) was collected from the abdominal aorta and animals were decapitated. The left kidney was surgically removed and stored at -70°C for subsequent analysis. KEY FINDINGS: An increase was observed in creatinine and urea levels, superoxide production, antioxidant enzymes, and oxidative damage in the CKD group, as compared to sham animals (p<0.05). Physical training made superoxide production and oxidative damage decrease in the CKD group (p<0.05), increasing SOD and GPX activity, though it did not increase the antioxidant effects of CAT, and renal parameters. SIGNIFICANCE: Even without altering renal function in animals induced to CKD model, the results show that physical training is an important component in the treatment of CKD, because it exerted a positive influence on oxidative stress parameters, in especially on the reduction in superoxide production and oxidative damage, as well as an improvement in the antioxidant defense system, like SOD and GPX.
Priscila Soares de Souza; Luis Gustavo Costa da Rocha; Camila Baumer Tromm; Débora Luz Sheffer; Eduardo Ghisi Victor; Paulo Cesar Lock da Silveira; Claudio Teodoro de Souza; Luciano Acordi Silva; Ricardo Aurino Pinho
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-7-3
Journal Detail:
Title:  Life sciences     Volume:  -     ISSN:  1879-0631     ISO Abbreviation:  -     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-7-9     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012. Published by Elsevier Inc.
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