Document Detail


Therapeutic targets for neuroprotection in acute ischemic stroke: lost in translation?
MedLine Citation:
PMID:  20626319     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The development of a suitable neuroprotective agent to treat ischemic stroke has failed when transitioned to the clinical setting. An understanding of the molecular mechanisms involved in neuronal injury during ischemic stroke is important, but must be placed in the clinical context. Current therapeutic targets have focused on the preservation of the ischemic penumbra in the hope of improving clinical outcomes. Unfortunately, most patients in the ultra-early time windows harbor penumbra but have tremendous variability in the size of the core infarct, the ultimate predictor of prognosis. Understanding this variability may allow for proper patient selection that may better correlate to bench models. Reperfusion therapies are rapidly evolving and have been shown to improve clinical outcomes. The use of neuroprotective agents to prolong time windows prior to reperfusion or to prevent reperfusion injury may present future therapeutic targets for the treatment of ischemic stroke. We review the molecular pathways and the clinical context from which future targets may be identified.
Authors:
Jeannette N Stankowski; Rishi Gupta
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-10-25
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  14     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-04-19     Completed Date:  2011-09-22     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1841-51     Citation Subset:  IM    
Affiliation:
Neuroscience Graduate Program, Vanderbilt University, Nashville, Tennessee, USA.
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MeSH Terms
Descriptor/Qualifier:
Humans
Neuroprotective Agents / therapeutic use*
Oxidative Stress / physiology
Reactive Oxygen Species / metabolism
Stroke / drug therapy*,  metabolism,  pathology,  physiopathology
Grant Support
ID/Acronym/Agency:
T32 MH064913/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
0/Neuroprotective Agents; 0/Reactive Oxygen Species
Comments/Corrections

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