| Therapeutic Strategies in Pulmonary Hypertension of the Newborn: where are we now? | |
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MedLine Citation:
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PMID: 22876901 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Despite recent advances, Persistent Pulmonary Hypertension of the Newborn (PPHN) still represents an important challenge for neonatologists. The care of newborns with PPHN requires meticulous therapeutic and ventilation strategies including, besides the stabilization of the newborn, the use of selective pulmonary vasodilators as inhaled Nitric Oxide (iNO). However, not all the neonates with PPHN are responsive to this clinical approach. Recent studies have proposed the use of alternative therapies to iNO, when it is not available, or there is no or only a transitory response. Sildenafil, a phosphodiesterase 5 inhibitor, appears as a frequent used therapy in refractory forms of PPHN. The aim of this review is to analyze the current therapeutic strategies in PPHN with special emphasis on iNO. |
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Authors:
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Manuel Sanchez Luna; Luisa Franco; Belén Bernardo |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-8-09 |
Journal Detail:
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Title: Current medicinal chemistry Volume: - ISSN: 1875-533X ISO Abbreviation: Curr. Med. Chem. Publication Date: 2012 Aug |
Date Detail:
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Created Date: 2012-8-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9440157 Medline TA: Curr Med Chem Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Neonatology Division, Hospital General Universitario "Gregorio Marañón" Dr Esuqerdo 46, 28009 Madrid, Spain. msanchezl.hgugm@salud.madrid.org. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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