| The Therapeutic Potential of HDAC Inhibitors in the Treatment of Multiple Sclerosis. | |
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MedLine Citation:
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PMID: 21373721 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Multiple sclerosis (MS) is a devastating autoimmune disorder of the CNS for which there is no efficacious cure. Thanks to the numerous preclinical and clinical studies, drugs able to mitigate the inexorable course of the disease have been recently made available. Still, there is terrible need for compounds capable of reducing the severity of the autoimmune attack, and block progression of MS. Also, besides the classic immune-suppressive strategies, it is now appreciated that compounds directly targeting neuronal death can be of relevance to treatment of MS patients. Acetylation homeostasis is a key regulator of both immune cell activation and neuronal survival. Of note, potent inhibitors of histone deacetylases (HDACi) endowed with anti-inflammatory and neuroprotective properties have been identified. Consistently, efficacy of HDACi in experimental models of MS has been reported. In this review, we provide an appraisal of the literature on HDACi and MS, also discussing the mechanisms by which HDACi can suppress the autoimmune attack to the CNS. |
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Authors:
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Giuseppe Faraco; Leonardo Cavone; Alberto Chiarugi |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-2-25 |
Journal Detail:
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Title: Molecular medicine (Cambridge, Mass.) Volume: - ISSN: 1528-3658 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-3-4 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9501023 Medline TA: Mol Med Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Division of Neurobiology, Department of Neurology and Neuroscience, Weill Cornell Medical College, New York, USA, and Department of Preclinical and Clinical Pharmacology, University of Florence, Florence, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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