| The therapeutic implications of Renin-Angiotensin system blockade in diabetic retinopathy. | |
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MedLine Citation:
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PMID: 20939795 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Research has proven that blood pressure is an important modifiable risk factor for diabetic retinopathy and that lowering high blood pressure significantly reduces the development and progression of retinopathy in both type 1 and type 2 diabetic patients. The renin-angiotensin-system (RAS) has been shown to become activated in diabetes. Hyperglycaemia stimulates the angiotensin AT1-receptor and downstream chains of events resulting in diabetic end organ damage. Pharmacological RAS inhibition may thus be a beneficial therapeutic strategy in the management of diabetic retinopathy. The present review article details therapeutic RAS inhibition in diabetic retinopathy with an emphasis on recently published evidence. Future research on the potential effects of RAS blockade will be important while using these drugs as adjuncts in the treatment of diabetic retinopathy. |
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Authors:
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V Swetha Jeganathan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Current pharmaceutical biotechnology Volume: 12 ISSN: 1873-4316 ISO Abbreviation: Curr Pharm Biotechnol Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100960530 Medline TA: Curr Pharm Biotechnol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 392-5 Citation Subset: IM |
Affiliation:
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Tun Hussein Onn National Eye Hospital, Lorong Utara B, 46200 Petaling Jaya, Selangor Darul Ehsan, Malaysia. vswetha@ausdoctors.net. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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