Document Detail

Therapeutic exercise during outpatient radiation therapy for advanced cancer: Feasibility and impact on physical well-being.
MedLine Citation:
PMID:  20531162     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To characterize the feasibility of delivering a structured physical therapy (PT) program as part of a multidisciplinary intervention to patients undergoing outpatient radiation therapy for advanced cancer. DESIGN: A single-blinded, randomized, controlled trial at a quaternary medical center outpatient clinic. One hundred three adults undergoing radiation therapy for advanced cancer with prognoses > or =6 mos and 5-yr survival estimates < or =50% were randomized to usual care or participation in eight 90-min, multidisciplinary interventional sessions with 30 mins of each session devoted to PT. PT consisted of truncal and limb isodynamic strengthening targeting major upper- and lower-limb muscle groups as well as education and provision with instructional materials. Physical well-being and fatigue were assessed with Linear Analog Scale of Assessment. The Profile of Mood States-Short form, including Fatigue-Inertia and Vigor-Activity subscales, was also administered. RESULTS: PT session attendance was 89.3%. Relative to baseline, mean physical well-being Linear Analog Self Assessment scores at week 4 improved in the intervention group, 0.4 (SD, 23.6), and declined significantly in the control group, -10.0 (SD, 21.5) (P = 0.02). Fatigue and vigor were not significantly different between the groups. All intergroup differences had resolved at 8 and 27 wks. Baseline characteristics were not associated with the magnitude or direction of change in outcomes related to physical functioning. CONCLUSIONS: Delivery of a standardized resistive exercise PT intervention is feasible during outpatient radiation therapy and is associated with preserved physical well-being. However, benefits were not sustained, and fatigue was not affected.
Andrea L Cheville; Jean Girardi; Matthew M Clark; Teresa A Rummans; Thomas Pittelkow; Paul Brown; Jean Hanson; Pamela Atherton; Mary E Johnson; Jeff A Sloan; Gail Gamble
Publication Detail:
Type:  Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  American journal of physical medicine & rehabilitation / Association of Academic Physiatrists     Volume:  89     ISSN:  1537-7385     ISO Abbreviation:  Am J Phys Med Rehabil     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-21     Completed Date:  2010-08-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803677     Medline TA:  Am J Phys Med Rehabil     Country:  United States    
Other Details:
Languages:  eng     Pagination:  611-9     Citation Subset:  AIM; IM    
Departments of Physical Medicine and Rehabilitation, Mayo Clinic, Rochester, Minnesota, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Fatigue / epidemiology
Feasibility Studies
Middle Aged
Neoplasms / psychology*,  radiotherapy*
Outpatient Clinics, Hospital
Physical Therapy Modalities*
Quality of Life*
Single-Blind Method

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Extra- and Intramuscular Nerve Distribution Patterns of the Muscles of the Ventral Compartment of th...
Next Document:  Extra-articular osteochondromatosis.