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Therapeutic Efficacy of Artemether-Lumefantrine for the Treatment of Uncomplicated Plasmodium falciparum Malaria in Northern Ethiopia.
MedLine Citation:
PMID:  22567536     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Introduction. Multidrug resistance of Plasmodium falciparum is spreading throughout Africa. This has posed major challenges to malaria control in sub-Saharan Africa. Objective. The aim of the study was to evaluate the efficacy of artemether-lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in North Ethiopia. Methods. This prospective study was undertaken during August-November 2009 on 71 malaria patients that fulfilled the inclusion criteria set by the WHO. Patients were followed up for 28 days. Thick and thin blood films were prepared by Giemsa stain for microscopy to determine parasite density. A standard six-dose regimen of artemether-lumefantrine was administered over three days and was followed up with clinical and parasitological evaluations over 28 days. Results. The cure rate (ACPR) was found to be high (97.2%) in this study. The parasite and fever clearance time was also rapid. Artemether-lumefantrine for the treatment of acute uncomplicated Plasmodium falciparum malaria in the study area showed 97.2% cure rate and only 2.8% failure rate. Conclusion. The result showed that the drug could continue as first line for the treatment of uncomplicated Plasmodium falciparum malaria in the study area. The efficacy of artemether-lumefantrine needs to be carefully monitored periodically in sentinel sites representing different areas of the country.
Authors:
Gebremedhin Kinfu; Solomon Gebre-Selassie; Nigus Fikrie
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Publication Detail:
Type:  Journal Article     Date:  2012-04-11
Journal Detail:
Title:  Malaria research and treatment     Volume:  2012     ISSN:  2044-4362     ISO Abbreviation:  Malar Res Treat     Publication Date:  2012  
Date Detail:
Created Date:  2012-05-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101568072     Medline TA:  Malar Res Treat     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  548710     Citation Subset:  -    
Affiliation:
Tigrai Region Health Bureau, B.O. BOX 7, Mekelle, Tigrai, Ethiopia.
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