| Therapeutic effects of hyaluronan on smoke-induced elastic fiber injury: does delayed treatment affect efficacy? | |
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MedLine Citation:
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PMID: 21153833 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Aerosolized hyaluronan (HA) has been previously shown to prevent cigarette smoke-induced airspace enlargement and elastic fiber injury in mice when given concurrently with smoke. In the present study, a more stringent test of the therapeutic potential of HA was performed by delaying treatment with this agent for 1 month. After treatment with cigarette smoke for 3 h per day for 5 days per week for 1 month, mice (DBA/2J) began receiving aerosolized HA (0.1%) for 1 h prior to smoke exposure (controls were given aerosolized water). The results indicate that much of the damage to the lung elastic fibers occurred within the first several months of smoke exposure, as measured by levels of desmosine and isodesmosine (DID) in bronchoalveolar lavage fluid (BALF). In contrast to previously published studies, where concurrent administration of aerosolized HA significantly reduced BALF DID levels within 3 months of smoke exposure, the same effect was not seen until 6 months when HA treatment was delayed. However, despite the prolonged breakdown of elastic fibers in the current study, a significant reduction in airspace enlargement was observed after only 2 months of HA treatment. These findings provide further support for testing this agent in patients with pre-existing chronic obstructive pulmonary disease. |
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Authors:
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Jerome O Cantor; Joseph M Cerreta; Marcos Ochoa; Shuren Ma; Ming Liu; Gerard M Turino |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-12-14 |
Journal Detail:
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Title: Lung Volume: 189 ISSN: 1432-1750 ISO Abbreviation: Lung Publication Date: 2011 Feb |
Date Detail:
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Created Date: 2011-02-17 Completed Date: 2011-06-13 Revised Date: 2012-02-02 |
Medline Journal Info:
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Nlm Unique ID: 7701875 Medline TA: Lung Country: United States |
Other Details:
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Languages: eng Pagination: 51-6 Citation Subset: IM |
Affiliation:
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St Luke's Roosevelt Hospital Center, New York, NY, USA. jocantor@pol.net |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Inhalation Aerosols Animals Bronchoalveolar Lavage Fluid / chemistry Desmosine / metabolism Disease Models, Animal Dose-Response Relationship, Drug Elastic Tissue / drug effects*, metabolism, pathology Female Hyaluronic Acid / administration & dosage, pharmacology* Isodesmosine / metabolism Lung / drug effects*, metabolism, pathology Mice Mice, Inbred DBA Pulmonary Disease, Chronic Obstructive / drug therapy*, etiology, metabolism, pathology Pulmonary Emphysema / drug therapy*, etiology, metabolism, pathology Smoking / adverse effects* Time Factors |
| Grant Support | |
ID/Acronym/Agency:
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HL68383/HL/NHLBI NIH HHS; R41 HL068383-01/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Aerosols; 11003-57-9/Desmosine; 9004-61-9/Hyaluronic Acid; 991-01-5/Isodesmosine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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