Document Detail


Therapeutic effects of hyaluronan on smoke-induced elastic fiber injury: does delayed treatment affect efficacy?
MedLine Citation:
PMID:  21153833     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aerosolized hyaluronan (HA) has been previously shown to prevent cigarette smoke-induced airspace enlargement and elastic fiber injury in mice when given concurrently with smoke. In the present study, a more stringent test of the therapeutic potential of HA was performed by delaying treatment with this agent for 1 month. After treatment with cigarette smoke for 3 h per day for 5 days per week for 1 month, mice (DBA/2J) began receiving aerosolized HA (0.1%) for 1 h prior to smoke exposure (controls were given aerosolized water). The results indicate that much of the damage to the lung elastic fibers occurred within the first several months of smoke exposure, as measured by levels of desmosine and isodesmosine (DID) in bronchoalveolar lavage fluid (BALF). In contrast to previously published studies, where concurrent administration of aerosolized HA significantly reduced BALF DID levels within 3 months of smoke exposure, the same effect was not seen until 6 months when HA treatment was delayed. However, despite the prolonged breakdown of elastic fibers in the current study, a significant reduction in airspace enlargement was observed after only 2 months of HA treatment. These findings provide further support for testing this agent in patients with pre-existing chronic obstructive pulmonary disease.
Authors:
Jerome O Cantor; Joseph M Cerreta; Marcos Ochoa; Shuren Ma; Ming Liu; Gerard M Turino
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-12-14
Journal Detail:
Title:  Lung     Volume:  189     ISSN:  1432-1750     ISO Abbreviation:  Lung     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-17     Completed Date:  2011-06-13     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  7701875     Medline TA:  Lung     Country:  United States    
Other Details:
Languages:  eng     Pagination:  51-6     Citation Subset:  IM    
Affiliation:
St Luke's Roosevelt Hospital Center, New York, NY, USA. jocantor@pol.net
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MeSH Terms
Descriptor/Qualifier:
Administration, Inhalation
Aerosols
Animals
Bronchoalveolar Lavage Fluid / chemistry
Desmosine / metabolism
Disease Models, Animal
Dose-Response Relationship, Drug
Elastic Tissue / drug effects*,  metabolism,  pathology
Female
Hyaluronic Acid / administration & dosage,  pharmacology*
Isodesmosine / metabolism
Lung / drug effects*,  metabolism,  pathology
Mice
Mice, Inbred DBA
Pulmonary Disease, Chronic Obstructive / drug therapy*,  etiology,  metabolism,  pathology
Pulmonary Emphysema / drug therapy*,  etiology,  metabolism,  pathology
Smoking / adverse effects*
Time Factors
Grant Support
ID/Acronym/Agency:
HL68383/HL/NHLBI NIH HHS; R41 HL068383-01/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Aerosols; 11003-57-9/Desmosine; 9004-61-9/Hyaluronic Acid; 991-01-5/Isodesmosine
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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