| Therapeutic Drug Monitoring of Voriconazole After Intravenous Administration in Infants and Children With Primary Immunodeficiency. | |
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MedLine Citation:
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PMID: 21743382 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: A voriconazole trough concentration (Ctrough) <1 mg/L is associated with a higher risk of treatment failure. The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole. METHODS:: Voriconazole trough concentrations obtained during routine therapeutic drug monitoring over a 5-year period were collected retrospectively from infants and children receiving intravenous voriconazole for presumed or proven invasive fungal infections. RESULTS:: Sixty-two trough concentrations were obtained from 6 infants and 10 children. The risk of a Ctrough <1 mg/L was 77% and 47%, respectively. Daily doses between 20 and 32 mg/kg were necessary in some patients to achieve a Ctrough >1 mg/L, compared with the currently recommended 14-mg/kg regimen. CONCLUSIONS:: Routine therapeutic drug monitoring is potentially helpful in infants and children receiving voriconazole, even intravenously. |
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Authors:
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Magdalena Gerin; Nizar Mahlaoui; Caroline Elie; Fanny Lanternier; Marie-Elisabeth Bougnous; Stéphane Blanche; Olivier Lortholary; Vincent Jullien |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-02 |
Journal Detail:
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Title: Therapeutic drug monitoring Volume: - ISSN: 1536-3694 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-11 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7909660 Medline TA: Ther Drug Monit Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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From the *Université Paris Descartes, Assistance Publique-Hôpitaux de Paris; †Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur; ‡Hôpital Necker-Enfants Malades; §Unité d'Immunologie-Hématologie Pédiatriques; ¶Service de Biostatistique; ‖Service de Microbiologie; **Institut Pasteur, Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire; ††CNRS URA 3012; ‡‡Service de Pharmacologie Clinique; Inserm U663; Hôpital Saint-Vincent de Paul, Paris, France; §§Centre de Référence Déficits Immunitaires Héréditaires. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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