Document Detail


Therapeutic Drug Monitoring of Voriconazole After Intravenous Administration in Infants and Children With Primary Immunodeficiency.
MedLine Citation:
PMID:  21743382     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
OBJECTIVE:: A voriconazole trough concentration (Ctrough) <1 mg/L is associated with a higher risk of treatment failure. The aim of this work was to describe the probability of not achieving this target concentration in infants and children receiving intravenous voriconazole. METHODS:: Voriconazole trough concentrations obtained during routine therapeutic drug monitoring over a 5-year period were collected retrospectively from infants and children receiving intravenous voriconazole for presumed or proven invasive fungal infections. RESULTS:: Sixty-two trough concentrations were obtained from 6 infants and 10 children. The risk of a Ctrough <1 mg/L was 77% and 47%, respectively. Daily doses between 20 and 32 mg/kg were necessary in some patients to achieve a Ctrough >1 mg/L, compared with the currently recommended 14-mg/kg regimen. CONCLUSIONS:: Routine therapeutic drug monitoring is potentially helpful in infants and children receiving voriconazole, even intravenously.
Authors:
Magdalena Gerin; Nizar Mahlaoui; Caroline Elie; Fanny Lanternier; Marie-Elisabeth Bougnous; Stéphane Blanche; Olivier Lortholary; Vincent Jullien
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-7-02
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  -     ISSN:  1536-3694     ISO Abbreviation:  -     Publication Date:  2011 Jul 
Date Detail:
Created Date:  2011-7-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
From the *Université Paris Descartes, Assistance Publique-Hôpitaux de Paris; †Service de Maladies Infectieuses et Tropicales, Centre d'Infectiologie Necker-Pasteur; ‡Hôpital Necker-Enfants Malades; §Unité d'Immunologie-Hématologie Pédiatriques; ¶Service de Biostatistique; ‖Service de Microbiologie; **Institut Pasteur, Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire; ††CNRS URA 3012; ‡‡Service de Pharmacologie Clinique; Inserm U663; Hôpital Saint-Vincent de Paul, Paris, France; §§Centre de Référence Déficits Immunitaires Héréditaires.
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