Document Detail


Therapeutic Drug Monitoring of Common Antipsychotics.
MedLine Citation:
PMID:  23149440     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT:: The aim of this review is to provide information for interpreting outcome results from monitoring of antipsychotics in biological samples. A brief overview of the working mechanisms, pharmacological effects, drug interactions, and analytical methods of classical and atypical antipsychotics is given. Nineteen antipsychotics were selected based on their importance in the worldwide market as follows: amisulpride, aripiprazole, asenapine, bromperidol, clozapine, flupenthixol, haloperidol, iloperidone, lurasidone, olanzapine, paliperidone, perphenazine, pimozide, pipamperone, quetiapine, risperidone, sertindole, sulpiride, and zuclopenthixol. A straightforward relationship between administered dose, plasma or serum concentration, clinical outcome, or adverse effects is often lacking. Nowadays, focus lies on therapeutic drug monitoring and individualized therapy to find adequate treatment, to explain treatment failure or nonresponse, and to check patient compliance. However, extensive research in this field is still mandatory.
Authors:
Lisbeth Patteet; Manuel Morrens; Kristof E Maudens; Peter Niemegeers; Bernard Sabbe; Hugo Neels
Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  Therapeutic drug monitoring     Volume:  34     ISSN:  1536-3694     ISO Abbreviation:  Ther Drug Monit     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7909660     Medline TA:  Ther Drug Monit     Country:  -    
Other Details:
Languages:  ENG     Pagination:  629-651     Citation Subset:  -    
Affiliation:
*Toxicological Centre, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium †Faculty of Medicine, Collaborative Antwerp Psychiatric Research Institute, University of Antwerp, Universiteitsplein 1, Antwerp, Belgium ‡Psychiatric Hospital Broeders Alexianen, Provinciesteenweg, Boechout, Belgium §Psychiatric Centre Sint-Norbertushuis, Stationstraat, Duffel, Belgium ¶Laboratory for TDM and toxicology, ZNA Stuivenberg, Lange Beeldekensstraat, Antwerpen, Belgium.
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