Document Detail


Theories on the nature of the coupling between ventilation and gas exchange during exercise.
MedLine Citation:
PMID:  16412707     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
For over a century of creative research, many theories on the possible mechanisms controlling respiration during exercise have been developed and discussed. One of the most enduring questions is certainly related to the mechanisms that can prevent P(a)(CO(2)) rising when CO(2) production increases. As multiple systems and structures are capable of increasing ventilation (V (E)), not all the mechanisms controlling respiration can provide a proper answer to this question. Indeed, exercise is a complex physiological condition combining motor activity with a change in metabolic rate. The most intriguing aspect of exercise is that when the changes in metabolism are dissociated from the motor and locomotor activity, the strategy 'chosen' by the respiratory control system is to follow the metabolic rate (or more precisely factors temporally associated with the pulmonary gas exchange rate) regardless of the motor act. The strategy used by the respiratory system during exercise therefore appears to select from among various sources of information the most relevant to follow the rate at which CO(2) is ultimately exchanged by the lungs. Yet, the nature of the signal(s) which prevents CO(2)/H(+) disturbance during exercise is the fundamental question addressed by this simple observation and remains to be clarified. This review illustrates the attempts of many physiologists to collect experimental evidence for theories which could provide satisfactory mechanisms accounting for the matching between ventilation and the rate at which CO(2) leaves the tissues and is exchanged at the lungs. More recent models based on somatic information of circulatory origin are presented and discussed.
Authors:
Philippe Haouzi
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Publication Detail:
Type:  Journal Article; Review     Date:  2006-01-10
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  151     ISSN:  1569-9048     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-04-17     Completed Date:  2006-07-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  267-79     Citation Subset:  IM    
Affiliation:
Laboratoire de Physiologie, Faculté de Médecine de Nancy, Avenue de la Forêt de Haye, B.P. 184, 54505 Vandoeuvre-lès-Nancy Cedex, France. p.haouzi@chu-nancy.fr
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MeSH Terms
Descriptor/Qualifier:
Animals
Blood Pressure / physiology
Carbon Dioxide / metabolism
Exercise / physiology*
Heart Rate / physiology
Humans
Models, Biological*
Motor Activity / physiology
Papaverine / therapeutic use
Protons
Pulmonary Gas Exchange / physiology*
Respiratory Mechanics / physiology*
Time Factors
Ventricular Outflow Obstruction / drug therapy,  physiopathology
Chemical
Reg. No./Substance:
0/Protons; 124-38-9/Carbon Dioxide; 58-74-2/Papaverine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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