Document Detail

Theories of adaptation: what they do and don't say.
MedLine Citation:
PMID:  15881676     Owner:  NLM     Status:  MEDLINE    
Theoretical work on adaptation has lagged behind experimental. But two classes of adaptation model have been partly explored. One is phenotypic and the other DNA sequence based. I briefly consider an example of each--Fisher's geometric model and Gillespie's mutational landscape model, respectively--reviewing recent results. Despite their fundamental differences, these models give rise to several strikingly similar results. I consider possible reasons for this congruence. I also emphasize what predictions do and, as important, do not follow from these models.
H Allen Orr
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Genetica     Volume:  123     ISSN:  0016-6707     ISO Abbreviation:  Genetica     Publication Date:  2005 Feb 
Date Detail:
Created Date:  2005-05-09     Completed Date:  2005-07-28     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0370740     Medline TA:  Genetica     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3-13     Citation Subset:  IM    
Department of Biology, University of Rochester, Rochester, NY 14627, USA.
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MeSH Terms
Adaptation, Biological / genetics*
Models, Genetic
Quantitative Trait Loci
Selection, Genetic*
Grant Support
2R01 G51932-06A1//PHS HHS

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