Document Detail


Theoretical study of cardiac transient conduction blocks on reentries induction. Applications to antiarrhythmic drugs.
MedLine Citation:
PMID:  9436297     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Limitations of antiarrhythmic drugs on cardiac sudden death prevention appeared since the early 80's. The "Cardiac Arrhythmia Suppression Trial" (CAST) showed more recently that mortality was significantly higher in patients treated with some particular antiarrhythmic drugs than in non-treated patients. In this field, our group recently demonstrated that a bolus of a Class 1 B antiarrhythmic drug was able to trigger a ventricular fibrillation due to transient blocks induction. The aim of the present work was to systematically study, by use of the van Capelle and Durrer (VCD) model which allows to simulate ventricular activation wave propagation, the link between arrhythmogenic effects and the ability of transient blocks to possibly degenerate in severe arrhythmias. A fragment of the ventricular wall is represented by an array of 16384 elements electrically coupled. Effects of induction of one or several transient blocks, as the effects of their size and duration on possible induction of reentries have been studied. Results obtained show that various combinations between these different parameters may trigger reentries, ventricular tachycardia and/or more complex patterns assimilable to ventricular fibrillation. These results clearly evidence the fact that possible induction of transient blocks may directly be related to risk factor associated to arrhythmogenic effects of antiarrhythmic drugs.
Authors:
A L Bardou; P M Auger; J L Chasse; R Seigneuric
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta biotheoretica     Volume:  45     ISSN:  0001-5342     ISO Abbreviation:  Acta Biotheor.     Publication Date:  1997 Nov 
Date Detail:
Created Date:  1998-02-24     Completed Date:  1998-02-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0421520     Medline TA:  Acta Biotheor     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  227-36     Citation Subset:  IM    
Affiliation:
Cardiologie Théorique, CHU Pitié-Salpétrière, Paris.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Arrhythmia Agents / administration & dosage,  adverse effects*
Cardiac Pacing, Artificial
Electrocardiography / drug effects*
Heart Block / chemically induced*,  physiopathology
Heart Conduction System / drug effects,  physiopathology
Heart Ventricles / drug effects,  physiopathology
Humans
Models, Cardiovascular
Models, Theoretical
Tachycardia, Atrioventricular Nodal Reentry / chemically induced*,  physiopathology
Ventricular Fibrillation / chemically induced*,  physiopathology
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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