Document Detail

Theoretical prediction of the stability and intramolecular rearrangement reactions of heteroanalogues of cyclopropylcarbene: 2-oxiranyl-, 2-aziridinyl-, and 1-aziridinylcarbene
MedLine Citation:
PMID:  10814098     Owner:  NLM     Status:  Publisher    
Ab initio studies have been carried out on the experimentally uncharacterized 2-oxiranyl- (8), fluoro-2-oxiranyl- (15), 2-aziridinyl- (21), and 1-aziridinylcarbene (29) on the B3LYP/6-31G(d) and CCSD(T)/6-31G(d,p)//MP2/6-31G(d,p) levels of theory. Like the parent cyclopropylcarbene (1), the beta-heterosubstituted carbenes 8 and 21-intermediates in the Eschenmoser-Tanabe fragmentation-are predicted to give either ethyne extrusion or ring expansion reactions, depending on the initial conformation. The barriers for these reactions are low (<6 kcal mol(-)(1)), while the interconversion of the carbene conformers requires higher energies. NBO analyses show that the donor-acceptor interactions between the carbene frontier orbitals and sigma-bond orbitals in the oxiranyl and aziridinyl ring destabilize the compounds kinetically. 2-Oxiranyl- and 2-aziridinylcarbenes with a fixed cis (=exo) conformation are predicted to rearrange to the heteroanalogue derivatives of cyclobutene. The fluoro-substituted 2-oxiranylcarbene 15 is predicted to rearrange to the substituted oxete via one equilibrated conformer, due to the low barrier of the C-(CF)-rotation. 1-Aziridinylcarbene 29 is the thermodynamically most stable of the investigated carbenes; however, the fragmentation into HCN and ethene is a facile reaction with a calculated barrier of 15 kcal mol(-)(1), which confirms experiments.
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Publication Detail:
Journal Detail:
Title:  The Journal of organic chemistry     Volume:  65     ISSN:  1520-6904     ISO Abbreviation:  J. Org. Chem.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-09-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985193R     Medline TA:  J Org Chem     Country:  UNITED STATES    
Other Details:
Languages:  Eng     Pagination:  1366-75     Citation Subset:  -    
Organisch-Chemisches Institut, Westfalische Wilhelms-Universitat, Corrensstrasse 40, D-48149 Munster, Germany.
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