Document Detail


Theoretical and experimental assessment of the kinetic properties of N-isopropyl-p-[123I]iodoamphetamine in the human brain.
MedLine Citation:
PMID:  7512225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effect of the loss of radioactivity from the human brain on the measurement of regional cerebral blood flow (rCBF) using N-isopropyl-p-[123I]iodoamphetamine (IMP) was evaluated by measuring rCBF in 10 normal male volunteers from 0.5 to 30 minutes after intravenous administration. rCBF was calculated by the operational equation, which assumes no product loss. Brain tissue and arterial blood concentration data were plotted according to a multiple-time/graphic evaluation technique. Data were fitted to the kinetic three-compartment model to estimate four kinetic rate constants to evaluate activity loss from the brain. These studies showed that loss of activity from the brain is negligible during the first 5 minutes, but after 7.5 minutes the loss becomes significantly higher with time. The present study corroborates the necessity for using single photon emission computed tomographic images measured within 5 minutes of IMP injection to quantify rCBF.
Authors:
K Mori; K Nakajima; M Maeda
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurologia medico-chirurgica     Volume:  33     ISSN:  0470-8105     ISO Abbreviation:  Neurol. Med. Chir. (Tokyo)     Publication Date:  1993 Dec 
Date Detail:
Created Date:  1994-05-06     Completed Date:  1994-05-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0400775     Medline TA:  Neurol Med Chir (Tokyo)     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  809-14     Citation Subset:  IM    
Affiliation:
Department of Neurosurgery, Juntendo University Izunagaoka Hospital, Shizuoka.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Amphetamines / analysis,  diagnostic use,  pharmacokinetics*
Blood-Brain Barrier / drug effects
Brain / metabolism*,  physiology,  radiography
Cerebrovascular Circulation / drug effects,  physiology
Humans
Iofetamine
Male
Middle Aged
Models, Biological
Regional Blood Flow / physiology*
Tomography, Emission-Computed, Single-Photon
Chemical
Reg. No./Substance:
0/Amphetamines; 95896-48-3/Iofetamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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