Document Detail

Theoretical and experimental approach to recognition of amino acid by tRNA.
MedLine Citation:
PMID:  6664848     Owner:  NLM     Status:  MEDLINE    
The C4N model concludes that the pocket on the complex of the anticodon bases and the discriminator base on a tRNA can accept the corresponding protein amino acid. A theoretical molecular computation by using the energy minimum principle is carried out to find the energy-refined C4N conformation. The results for Gln and Val suggest that not only the lock and key relationship but the induced fitting effect occurs. Some experiments to detect the interaction between the polynucleotides and the amino acid are being attempted.
S Yoneda; M Shimizu; N Go; S Fujii; M Uchida; K Miura; K Watanabe
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nucleic acids symposium series     Volume:  -     ISSN:  0261-3166     ISO Abbreviation:  Nucleic Acids Symp. Ser.     Publication Date:  1983  
Date Detail:
Created Date:  1984-03-16     Completed Date:  1984-03-16     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  8007206     Medline TA:  Nucleic Acids Symp Ser     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  145-8     Citation Subset:  IM    
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MeSH Terms
Amino Acids*
Genetic Code*
Models, Molecular
Nucleic Acid Conformation
RNA, Transfer*
Reg. No./Substance:
0/Amino Acids; 9014-25-9/RNA, Transfer

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