Document Detail


Theoretical development and critical analysis of burst frequency equations for passive valves on centrifugal microfluidic platforms.
MedLine Citation:
PMID:  23292292     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This paper presents a theoretical development and critical analysis of the burst frequency equations for capillary valves on a microfluidic compact disc (CD) platform. This analysis includes background on passive capillary valves and the governing models/equations that have been developed to date. The implicit assumptions and limitations of these models are discussed. The fluid meniscus dynamics before bursting is broken up into a multi-stage model and a more accurate version of the burst frequency equation for the capillary valves is proposed. The modified equations are used to evaluate the effects of various CD design parameters such as the hydraulic diameter, the height to width aspect ratio, and the opening wedge angle of the channel on the burst pressure.
Authors:
Tzer Hwai Gilbert Thio; Salar Soroori; Fatimah Ibrahim; Wisam Al-Faqheri; Norhayati Soin; Lawrence Kulinsky; Marc Madou
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2013-01-06
Journal Detail:
Title:  Medical & biological engineering & computing     Volume:  51     ISSN:  1741-0444     ISO Abbreviation:  Med Biol Eng Comput     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-04-16     Completed Date:  2013-11-26     Revised Date:  2014-05-07    
Medline Journal Info:
Nlm Unique ID:  7704869     Medline TA:  Med Biol Eng Comput     Country:  United States    
Other Details:
Languages:  eng     Pagination:  525-35     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Algorithms
Centrifugation / instrumentation
Compact Disks
Equipment Design
Hydrodynamics
Microfluidics / instrumentation*
Miniaturization
Models, Theoretical*
Grant Support
ID/Acronym/Agency:
1 R01 AI089541-01/AI/NIAID NIH HHS; R01 AI089541/AI/NIAID NIH HHS
Comments/Corrections

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