Document Detail

Theoretical analysis on cell size distribution and kinetics of foreign-body giant cell formation in vivo on polyurethane elastomers.
MedLine Citation:
PMID:  1429754     Owner:  NLM     Status:  MEDLINE    
The nature of in vivo leukocyte adhesion and foreign-body giant cell (FBGC) formation on polyurethanes was studied through theoretical and statistical analyses in terms of cell size distribution, density changes, and kinetics of FBGC formation. The results showed that the size distribution of FBGCs followed a "most probable" distribution. During FBGC formation, the densities of FBGCs changed with time. At an early stage, the number of FBGCs increased with time to a maximum at the expense of macrophages. As more FBGCs were formed and less macrophages were present, the fusion of FBGCs among themselves became significant. This, in turn, caused a gradual decrease of FBGC density with time. The rate of FBGC formation was characterized by a rate constant that represented certain characteristics of cell fusion and FBGC formation and the density of initial FBGC-forming macrophages that were a small fraction of leukocytes adhering to the surface. The direct correlations of surface cracking and pitting and adherent FBGCs demonstrated the influence of phagocytic actions of FBGCs on the biostability of implanted polyurethanes. While the cracking was thought to be caused by oxidative degradation facilitated by oxygen ion/radical release of FBGCs, the pitting appeared to result from the Methacrol 2138F aggregates diffusing out of the polymer in an acidic microenvironment under FBGCs, which in turn could be enhanced by the surface degradation and cell phagocytosis. The added Santowhite powder in polyurethane had a significant influence on FBGC formation: It reduced FBGC density and rate of FBGC formation by reducing leukocyte adhesion and the number of macrophages participating in FBGC formation.
O H Zhao; J M Anderson; A Hiltner; G A Lodoen; C R Payet
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of biomedical materials research     Volume:  26     ISSN:  0021-9304     ISO Abbreviation:  J. Biomed. Mater. Res.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-03     Completed Date:  1992-12-03     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0112726     Medline TA:  J Biomed Mater Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1019-38     Citation Subset:  IM    
Department of Macromolecular Science, Case Western Reserve University, Cleveland, Ohio 44106.
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MeSH Terms
Amines / chemistry,  isolation & purification
Cell Adhesion / drug effects
Cells / cytology*
Freeze Fracturing
Giant Cells, Foreign-Body* / drug effects
Hydrocarbons / chemistry,  isolation & purification
Hydrochloric Acid
Leukocytes* / cytology,  drug effects
Models, Statistical
Polyurethanes / chemistry*
Prostheses and Implants
Rats, Sprague-Dawley
Rubber / chemistry*
Surface Properties
Grant Support
Reg. No./Substance:
0/Amines; 0/Hydrocarbons; 0/Polyurethanes; 135640-50-5/Methacrol 2138F; 7647-01-0/Hydrochloric Acid; 9006-04-6/Rubber

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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