Document Detail


Theoretical analysis of altitude tolerance and hemoglobin function.
MedLine Citation:
PMID:  880179     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The potential effect of changes in the position and shape of the oxyhemoglobin dissociation curve (ODC) in modifying altitude tolerance is quantitatively analyzed and discussed. The most frequently used criteria for oxygen affinity, the position or P50 of the ODC (oxygen pressure at 50% saturation) is shown to have slight influence on tissue oxygenation in terms of arteriovenous oxygen difference under steady-state, hypoxic-hypoxia conditions. Conversely, changes in the shape of the curve, also expressed as the cooperativity or heme-heme interaction, could substantially modify oxygen transport under these conditions. Published observations are reviewed which suggest that hemoglobin cooperativity is not normally invariant.
Authors:
J R Neville
Related Documents :
5762189 - Hyperbaric oxygen: toxicity to fish at pressures present in their swimbladders.
9400789 - Systemic hyperoxia decreases vascular endothelial growth factor gene expression in isch...
11709429 - Oxygen diffusion and consumption of aortic valve cusps.
10579259 - Beneficial effects of helium:oxygen versus air:oxygen noninvasive pressure support in p...
22197199 - Does a simple bedside sonographic measurement of the inferior vena cava correlate to ce...
14636029 - Periodic breathing induced by arterial oxygen partial pressure oscillations.
3773499 - Effects of lobar pulmonary blood flow on the evolution of oleic acid lung injury in dogs.
9706929 - Incidence and time course of cardiovascular side effects during spinal anesthesia after...
8583479 - Discovery of losartan, the first angiotensin ii receptor antagonist.
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  48     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-12     Citation Subset:  IM; S    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Altitude*
Anoxia / metabolism
Heme / metabolism
Humans
Models, Biological
Oxygen / blood
Oxygen Consumption
Oxyhemoglobins / metabolism*
Chemical
Reg. No./Substance:
0/Oxyhemoglobins; 14875-96-8/Heme; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Catecholamine excretion in T-37 flight training.
Next Document:  Comparative orthostatic responses: standing vs. head-up tilt.