Document Detail

Theoretical analysis of altitude tolerance and hemoglobin function.
MedLine Citation:
PMID:  880179     Owner:  NLM     Status:  MEDLINE    
The potential effect of changes in the position and shape of the oxyhemoglobin dissociation curve (ODC) in modifying altitude tolerance is quantitatively analyzed and discussed. The most frequently used criteria for oxygen affinity, the position or P50 of the ODC (oxygen pressure at 50% saturation) is shown to have slight influence on tissue oxygenation in terms of arteriovenous oxygen difference under steady-state, hypoxic-hypoxia conditions. Conversely, changes in the shape of the curve, also expressed as the cooperativity or heme-heme interaction, could substantially modify oxygen transport under these conditions. Published observations are reviewed which suggest that hemoglobin cooperativity is not normally invariant.
J R Neville
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Aviation, space, and environmental medicine     Volume:  48     ISSN:  0095-6562     ISO Abbreviation:  Aviat Space Environ Med     Publication Date:  1977 May 
Date Detail:
Created Date:  1977-08-12     Completed Date:  1977-08-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7501714     Medline TA:  Aviat Space Environ Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  409-12     Citation Subset:  IM; S    
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MeSH Terms
Anoxia / metabolism
Heme / metabolism
Models, Biological
Oxygen / blood
Oxygen Consumption
Oxyhemoglobins / metabolism*
Reg. No./Substance:
0/Oxyhemoglobins; 14875-96-8/Heme; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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