| Theophylline-terbutaline, a steady state study on possible pharmacokinetic interactions with special reference to chronopharmacokinetic aspects. | |
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MedLine Citation:
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PMID: 3179168 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. The pharmacokinetic interaction of terbutaline and theophylline and chronopharmacokinetics of both drugs were studied in a three-way crossover study with repeated administration of terbutaline (Bricanyl Depot) 7.5 mg twice daily, theophylline (Theo-Dur) 300 mg twice daily alone or the combination of both for 7 days to 12 healthy volunteers (six male and six female). 2. After the morning dose on day 7, blood and urine were sampled for 12 h, and after the evening dose on day 7, blood and urine were sampled for 48 h. Theophylline concentrations in plasma and concentrations of unchanged drug and metabolites in urine were determined by two selective high performance liquid chromatography methods. Terbutaline concentrations in plasma and urine were measured with a gas chromatography-mass spectrometry method. Area under the plasma concentration-time curve, fluctuations in plasma concentration, mean residence time, elimination half-life, renal clearance as well as maximal, minimal and average plasma concentration at steady state were evaluated. 3. The addition of terbutaline to the repeated administration of theophylline lowered the relative bioavailability of theophylline by approximately 11% during the night interval. The rate of elimination of theophylline and mean residence time were influenced accordingly. No significant changes in excretion of the theophylline metabolites were observed, but the excretion of 3-methylxanthine was slightly reduced by the concomitant terbutaline administration. None of the observed changes should be of any clinical importance. 4. The addition of theophylline did not influence any of the calculated pharmacokinetic parameters of terbutaline. 5. It can be concluded that no dosage adjustment is necessary when terbutaline and theophylline are given together.(ABSTRACT TRUNCATED AT 250 WORDS) |
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Authors:
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J H Jonkman; L Borgström; W J van der Boon; O E de Noord |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: British journal of clinical pharmacology Volume: 26 ISSN: 0306-5251 ISO Abbreviation: Br J Clin Pharmacol Publication Date: 1988 Sep |
Date Detail:
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Created Date: 1988-12-02 Completed Date: 1988-12-02 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7503323 Medline TA: Br J Clin Pharmacol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 285-93 Citation Subset: IM |
Affiliation:
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State University of Groningen, Department of Analytical Chemistry and Toxicology, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Availability Drug Interactions Female Humans Male Terbutaline / administration & dosage, pharmacokinetics* Theophylline / administration & dosage, pharmacokinetics* Time |
| Chemical | |
Reg. No./Substance:
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23031-25-6/Terbutaline; 58-55-9/Theophylline |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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