| Theophylline for renal function in term neonates with perinatal asphyxia: a randomized, placebo-controlled trial. | |
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MedLine Citation:
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PMID: 16887430 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To study whether prophylactic theophylline can reduce the incidence and/or severity of renal failure in term infants with perinatal asphyxia. STUDY DESIGN: Term neonates with severe perinatal asphyxia were randomized to receive a single dose of either theophylline (study group, n = 40) or placebo (control group, n = 30) during the first hour of life. Daily weight, output/input ratio, 24-hour fluid intake, and urine volumes were recorded during the first 5 days of life. Those infants with asphyxial renal failure were followed up for 1 year. RESULTS: The incidence of severe renal dysfunction was increased in the control group. Creatinine clearance was higher and excretion of beta 2 microglobulin (beta2M) was lower in the theophylline group. Conversely, the glomerular filtration rate was lower in the control group. In infants with renal failure, serum creatinine and creatinine clearance returned to normal in the neonatal period, and the increased beta2M excretion normalized by age 6 weeks. CONCLUSIONS: A single dose of theophylline within the first hour of birth in term neonates with perinatal asphyxia results in a significant decrease in serum creatinine level and urinary excretion of beta2M, along with an increase in creatinine clearance. |
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Authors:
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Mushtaq A Bhat; Zaffar A Shah; Mudasir S Makhdoomi; Masood H Mufti |
Publication Detail:
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Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: The Journal of pediatrics Volume: 149 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-04 Completed Date: 2006-09-07 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 180-4 Citation Subset: AIM; IM |
Affiliation:
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Department of Pediatrics, Shere-Kashmir Institute of Medical Sciences (SKIMS), Soura, Srinagar, Kashmir, India. mbhat47@rediffmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Asphyxia Neonatorum
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drug therapy*,
epidemiology* Body Weight Creatinine / blood Glomerular Filtration Rate / physiology Humans Infant, Newborn Intensive Care Units, Neonatal Kidney Failure / epidemiology*, physiopathology, prevention & control* Severity of Illness Index Theophylline / therapeutic use* Vasodilator Agents / therapeutic use* beta 2-Microglobulin / urine |
| Chemical | |
Reg. No./Substance:
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0/Vasodilator Agents; 0/beta 2-Microglobulin; 58-55-9/Theophylline; 60-27-5/Creatinine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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