| Theophylline partially inhibits bronchoconstriction caused by inhaled histamine in subjects with asthma. | |
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MedLine Citation:
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PMID: 3958384 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Sixteen adult subjects in a clinical steady state had four consecutive histamine inhalation tests on the same day when they were not receiving oral theophylline medication. The provocative concentration of histamine causing a 20% fall in FEV1 (PC20) was used to assess the response. They were then administered active or placebo sustained-release theophylline preparations according to a double-blind, randomized 4.4.1. two-treatment crossover design. Medication was administered for a minimum of 3 consecutive days, and PC20 was reassessed on 4 different days, 3 to 4 hours after receiving active or placebo medication (two visits for each medication). A significant but small bronchodilator and blocking effect on histamine excitability was demonstrated for the active medication. This latter effect was present even by adjusting for changes in baseline airway caliber and for the intraindividual variability of the four PC20 values obtained on day 1. We conclude that theophylline partially blocks bronchial responsiveness to inhaled histamine. |
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Authors:
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A Cartier; I Lemire; J L'Archevêque; H Ghezzo; R R Martin; J L Malo |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of allergy and clinical immunology Volume: 77 ISSN: 0091-6749 ISO Abbreviation: J. Allergy Clin. Immunol. Publication Date: 1986 Apr |
Date Detail:
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Created Date: 1986-05-06 Completed Date: 1986-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1275002 Medline TA: J Allergy Clin Immunol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 570-5 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Asthma / blood, drug therapy Bronchial Provocation Tests Bronchial Spasm / chemically induced*, drug therapy Female Forced Expiratory Volume Histamine / administration & dosage, adverse effects* Humans Male Middle Aged Respiration Theophylline / blood, therapeutic use* |
| Chemical | |
Reg. No./Substance:
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51-45-6/Histamine; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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