Document Detail


Theophylline metabolism in preterm neonates during the first weeks of life.
MedLine Citation:
PMID:  6468225     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects of prenatal steroids on theophylline metabolism in infants of 27-32 weeks gestation was studied. Although in utero exposure to betamethasone was associated with a more mature theophylline metabolite pattern in the first days of life, initial elimination half-life (t1/2 beta) did not differ significantly between groups. By the second or third week of life the metabolite pattern was similar in all infants. The decline in t1/2 beta seen during theophylline treatment was not directly related to increased metabolite formation. These data suggest that other factors, such as renal clearance, are more important in determining the pharmacokinetics of theophylline in neonates than is hepatic metabolism.
Authors:
J Baird-Lambert; P E Doyle; D Thomas; E Jager-Roman; M Cvejic; N Buchanan
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Developmental pharmacology and therapeutics     Volume:  7     ISSN:  0379-8305     ISO Abbreviation:  Dev Pharmacol Ther     Publication Date:  1984  
Date Detail:
Created Date:  1984-10-03     Completed Date:  1984-10-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003947     Medline TA:  Dev Pharmacol Ther     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  239-44     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Betamethasone / therapeutic use
Female
Half-Life
Humans
Infant, Newborn
Infant, Premature*
Kidney / metabolism
Liver / metabolism
Maternal-Fetal Exchange
Pregnancy
Theophylline / metabolism*
Chemical
Reg. No./Substance:
378-44-9/Betamethasone; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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