Document Detail


Theophylline inhibition of renal and cerebral nucleoside formation.
MedLine Citation:
PMID:  7236996     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1 Theophylline inhibits the enzymatic formation of purine nucleosides, among these adenosine (dephosphorylated adenosine 5'-monophosphate), in kidney and brain of the rat. 2 Some pharmacological effects of theophylline on regional blood flow and electrophysiological activity of the nervous system may be caused by inhibition of the endogenous formation of adenosine.
Authors:
M H Jensen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  British journal of pharmacology     Volume:  73     ISSN:  0007-1188     ISO Abbreviation:  Br. J. Pharmacol.     Publication Date:  1981 Jun 
Date Detail:
Created Date:  1981-08-20     Completed Date:  1981-08-20     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7502536     Medline TA:  Br J Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  467-9     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain / metabolism*
Depression, Chemical
Kidney / metabolism*
Male
Phosphorylation
Purine Nucleosides / biosynthesis*
Rats
Theophylline / pharmacology*
Chemical
Reg. No./Substance:
0/Purine Nucleosides; 58-55-9/Theophylline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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