Document Detail

Theophylline disrupts diurnal rhythms of humoral factors with loss of meal cyclicity.
MedLine Citation:
PMID:  7043509     Owner:  NLM     Status:  MEDLINE    
To test the possibility that theophylline induced circadian disappearance of food intake might depend upon rhythmic disruption of blood glucose, insulin and free fatty acids (FFA), theophylline was administered chronically. This markedly lengthened postprandial intermeal intervals during the dark, and induced approximately identical intermeal intervals and identical meal sizes in the light and dark periods. In contrast to the clear light-dark dependent oscillations of serum glucose, insulin and FFA in the controls, the theophyllinized rats lost circadian fluctuation of each of these three chemical substances. Further, theophyllinized rats, unlike controls, had no time-dependent fluctuation in the levels of these substances at -120, -60 or -15 min preceding the onset of the first meal before the dark. These findings, together with previous reports, explain the disappearance of nocturnal feeding rhythm in theophyllinized rats in terms of functional destruction of circadian regulation in the hypothalamus which modulate the production of chemical determinants of food intake.
T Sakata; M Fukushima; K Tsutsui; K Arase; K Fujimoto
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  28     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1982 Apr 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  641-7     Citation Subset:  IM    
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MeSH Terms
Blood Glucose / metabolism*
Circadian Rhythm / drug effects*
Eating / drug effects*
Fatty Acids, Nonesterified / blood*
Insulin / blood*
Rats, Inbred Strains
Theophylline / pharmacology*
Reg. No./Substance:
0/Blood Glucose; 0/Fatty Acids, Nonesterified; 11061-68-0/Insulin; 58-55-9/Theophylline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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