Document Detail

Theophylline antagonizes cardiovascular responses to dipyridamole in man without affecting increases in plasma adenosine.
MedLine Citation:
PMID:  6475546     Owner:  NLM     Status:  MEDLINE    
Effects of the vasodilator dipyridamole (Dip) on plasma adenosine levels, heart rate, blood pressure and skin microcirculation were studied in 13 healthy male volunteers. Venous plasma concentrations of adenosine, catecholamines, dipyridamole and theophylline were determined by HPLC. Skin capillary blood cell velocity (CBV) was measured by videophotometric capillaroscopy in the finger nailfold. The adenosine uptake inhibitor Dip (approximately 1-3 microM in plasma) increased plasma adenosine from 0.15 +/- 0.03 to 0.29 +/- 0.03 microM (p less than 0.01) and heart rate (HR) by 13 +/- 2 beats/min (p less than 0.01) and reduced diastolic blood pressure by 6 +/- 2 mmHg (p less than 0.05). Dip did not significantly affect the skin circulation since basal CBV, digital pulse amplitude (DAPA), skin temperature and post-occlusive reactive hyperemia were unchanged. Plasma catecholamine levels were also unaffected. The adenosine receptor antagonist theophylline (45-55 microM in plasma) did not influence basal plasma catecholamine or adenosine levels, HR, blood pressure or skin microcirculation. Following theophylline Dip caused similar elevations of plasma adenosine but no changes in HR or blood pressures. Our results support the hypotheses that Dip dilates blood vessels in man by elevating endogenous adenosine and that theophylline acts as an adenosine antagonist. Under basal conditions, the skin microcirculation appears to be regulated mainly by factors other than adenosine.
A Sollevi; J Ostergren; B Fagrell; P Hjemdahl
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  121     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  1984 Jun 
Date Detail:
Created Date:  1984-10-17     Completed Date:  1984-10-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  165-71     Citation Subset:  IM    
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MeSH Terms
Adenosine / blood*
Blood Flow Velocity
Blood Pressure / drug effects
Catecholamines / blood
Dipyridamole / antagonists & inhibitors*,  pharmacology
Heart Rate / drug effects
Hemodynamics / drug effects*
Microcirculation / drug effects
Skin / blood supply
Theophylline / pharmacology*
Reg. No./Substance:
0/Catecholamines; 58-32-2/Dipyridamole; 58-55-9/Theophylline; 58-61-7/Adenosine

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