Document Detail


Theophylline cocrystals prepared by spray drying: physicochemical properties and aerosolization performance.
MedLine Citation:
PMID:  23297166     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The purpose of this work was to characterize theophylline (THF) cocrystals prepared by spray drying in terms of the physicochemical properties and inhalation performance when aerosolized from a dry powder inhaler. Cocrystals of theophylline with urea (THF-URE), saccharin (THF-SAC) and nicotinamide (THF-NIC) were prepared by spray drying. Milled THF and THF-SAC cocrystals were also used for comparison. The physical purity, particle size, particle morphology and surface energy of the materials were determined. The in vitro aerosol performance of the spray-dried cocrystals, drug-alone and a drug-carrier aerosol, was assessed. The spray-dried particles had different size distributions, morphologies and surface energies. The milled samples had higher surface energy than those prepared by spray drying. Good agreement was observed between multi-stage liquid impinger and next-generation impactor in terms of assessing spray-dried THF particles. The fine particle fractions of both formulations were similar for THF, but drug-alone formulations outperformed drug-carrier formulations for the THF cocrystals. The aerosolization performance of different THF cocrystals was within the following rank order as obtained from both drug-alone and drug-carrier formulations: THF-NIC>THF-URE>THF-SAC. It was proposed that micromeritic properties dominate over particle surface energy in terms of determining the aerosol performance of THF cocrystals. Spray drying could be a potential technique for preparing cocrystals with modified physical properties.
Authors:
Amjad Alhalaweh; Waseem Kaialy; Graham Buckton; Hardyal Gill; Ali Nokhodchi; Sitaram P Velaga
Related Documents :
12183116 - Measuring drug-related receptor occupancy with positron emission tomography.
17896986 - A novel functional approach toward identifying definitive drug targets.
20394436 - Half-antibody functionalized lipid-polymer hybrid nanoparticles for targeted drug deliv...
19594426 - The seattle structural genomics center for infectious disease (ssgcid).
19075886 - Microstructured devices for transdermal drug delivery and minimally-invasive patient mo...
23107966 - Novel thermo/ph sensitive nanogels composed from poly(n-vinylcaprolactam) for controlle...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-01-08
Journal Detail:
Title:  AAPS PharmSciTech     Volume:  14     ISSN:  1530-9932     ISO Abbreviation:  AAPS PharmSciTech     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2013-08-12     Revised Date:  2014-01-09    
Medline Journal Info:
Nlm Unique ID:  100960111     Medline TA:  AAPS PharmSciTech     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-76     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Aerosols*
Calorimetry, Differential Scanning
Chromatography, Gas
Microscopy, Electron, Scanning
Particle Size
Powder Diffraction
Theophylline / chemistry*
Chemical
Reg. No./Substance:
0/Aerosols; C137DTR5RG/Theophylline
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  The antinociceptive effect of milnacipran in the monosodium iodoacetate model of osteoarthritis pain...
Next Document:  Application of quality by design to the process development of botanical drug products: a case study...