| Theobromine kinetics and metabolic disposition. | |
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MedLine Citation:
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PMID: 6617078 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Metabolism and kinetics of a single oral dose of 30 microCi 8-14C-theobromine with 10 mg/kg theobromine sodium acetate were studied in six healthy, nonmedicated, nonsmoking men after 14 days' abstention from all methylxanthine sources. Identification and quantitation of metabolites in plasma and urine both by HPLC and by thin-layer chromatography coupled with radiography indicated that theobromine was predominant in plasma. For urine, both methods identified theobromine as well as 7-methylxanthine, 7-methyluric acid, 3-methylxanthine, 6-amino-5[N-methylformylamino]-1-methyluracil, and a small amount of 3,7-dimethyluric acid as the metabolites of theobromine. All administered radioactivity was recovered in urine and no polar metabolites could be detected. Analysis of the urinary excretion data by the sigma-minus method allowed calculation of the apparent first-order rate constants for production of 7-methylxanthine, 7-methyluric acid, 3-methylxanthine, 3,7-dimethyluric acid, and 6-amino-5[N-methylformylamino]-1-methyluracil. |
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Authors:
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S M Tarka; M J Arnaud; B H Dvorchik; E S Vesell |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Clinical pharmacology and therapeutics Volume: 34 ISSN: 0009-9236 ISO Abbreviation: Clin. Pharmacol. Ther. Publication Date: 1983 Oct |
Date Detail:
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Created Date: 1983-11-23 Completed Date: 1983-11-23 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0372741 Medline TA: Clin Pharmacol Ther Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 546-55 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Availability Chromatography, High Pressure Liquid Humans Kinetics Male Theobromine / metabolism* Time Factors |
| Chemical | |
Reg. No./Substance:
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83-67-0/Theobromine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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