| Thenar Oxygen Saturation (StO2) and Invasive Oxygen Delivery Measurements in Critically Ill Patients in Early Septic Shock. | |
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MedLine Citation:
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PMID: 21192279 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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OBJECTIVE:: This study was aimed to test the hypothesis that tissue hemoglobin oxygen saturation (StO2) measured non-invasively using near-infrared spectroscopy (NIRS) is a reliable indicator of global oxygen delivery (DO2) measured invasively using a pulmonary artery catheter (PAC) in patients with septic shock. DESIGN:: Prospective study. SETTING:: 26-bed medical-surgical ICU, at a university hospital. SUBJECTS:: Adult patients in septic shock who required PAC hemodynamic monitoring for resuscitation. INTERVENTIONS:: Transient ischemic challenge on the forearm. MEASUREMENTS:: After blood pressure normalization, hemodynamic and oximetric PAC variables and, simultaneously, steady-state StO2, and its changes from ischemic challenge (deoxygenation and reoxygenation rates). MAIN RESULTS:: Fifteen patients were studied. All the patients had a mean arterial pressure above 65 mmHg. The DO2 index (iDO2) range in the studied population was 215-674 mLO2/min/m. The mean mixed venous oxygen saturation (SvO2) value was 61 ± 10%, mean cardiac index (CI) 3.4 ± 0.9 L/min/m, and blood lactate 4.6 ± 2.7 mmol/L. Steady-state StO2 significantly correlated with iDO2, arterial and venous O2 content, and O2 extraction ratio. A StO2 cut-off value of 75% predicted iDO2 below 450 with a sensitivity (S) of 0.9, specificity (E) of 0.9. CONCLUSIONS:: In patients in septic shock and normalized MAP, low StO2 reflects extremely low iDO2. Steady-state StO2 does not correlate with moderately low iDO2, indicating poor sensitivity of StO2 to rule out hypoperfusion. |
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Authors:
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Jaume Mesquida; Guillem Gruartmoner; Maria Luisa Martínez; Jordi Masip; Caroline Sabatier; Cristina Espinal; Antonio Artigas; Francisco Baigorri |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-9 |
Journal Detail:
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Title: Shock (Augusta, Ga.) Volume: - ISSN: 1540-0514 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9421564 Medline TA: Shock Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Critical Care Center. Hospital de Sabadell. CIBER Enfermedades Respiratorias. Institut Universitari Parc Tauli. Universitat Autonoma de Barcelona. Barcelona, Spain. 2Department of Medicine. Universitat Autonoma de Barcelona. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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